Blowing up Neural Repair for Stroke Recovery: Preclinical and Clinical Trial Considerations.
Blowing up Neural Repair for Stroke Recovery: Preclinical and Clinical Trial Considerations.
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DOI：
10.1161/strokeaha.120.030486
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发表时间：
2020-10
期刊：
影响因子：
8.3
通讯作者：
Carmichael ST
中科院分区：
文献类型：
--
作者：
Ward NS;Carmichael ST
The repair and recovery of the brain after stroke is a field that is emerging in its pre-clinical science and clinical trials. However, recent large, multicenter clinical trials have been negative, and conflicting results emerge on biological targets in pre-clinical studies. The coalescence of negative clinical translation and confusion in pre-clinical studies raises the suggestion that perhaps the field of stroke recovery faces a fate similar to stroke neuroprotection, with interesting science ultimately proving difficult to translate to the clinic. This review highlights improvements in four areas of the stroke neural repair field that should re-orient the field toward successful clinical translation: improvements in rodent genetic models of stroke recovery, consideration of the biological target in stroke recovery, stratification in clinical trials, and the use of appropriate clinical trial endpoints.
