The spectrum of epidemiology underlying sudden cardiac death.
The spectrum of epidemiology underlying sudden cardiac death.
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DOI：
10.1161/circresaha.116.304521
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发表时间：
2015-06-05
影响因子：
20.1
通讯作者：
Albert CM
中科院分区：
文献类型：
--
作者：
Hayashi M;Shimizu W;Albert CM
心脏骤停的猝死（SCD）是一个主要的国际公共卫生问题，估计占所有死亡的15-20％。在患有结构性心脏病的老年人中，SCD的生存最常疾病。 CHD死亡的原因，SCD的一部分越来越多SCD潜在的病理和机制的异质性提出了预防SCD的主要挑战，这会通过在死亡之前经常缺乏对潜在的心脏状况的认识而进一步放大。我们将需要减少SCD的燃烧。一般人群和高风险子集都有既定的心脏病，都将重点放在最近的全球趋势，保持不确定性以及潜在的有针对性的预防策略上。
Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15–20% of all deaths. Although resuscitation rates are generally improving throughout the world, the majority of individuals who suffer a sudden cardiac arrest will not survive. SCD most often develops in older adults with acquired structural heart disease, but it also rarely occurs in the young, where it is more commonly due to inherited disorders. Coronary heart disease (CHD) is known to be the most common pathology underlying SCD, followed by cardiomyopathies, inherited arrhythmia syndromes, and valvular heart disease. Over the past three decades, declines in SCD rates have not been as steep as for other causes of CHD deaths, and there is a growing fraction of SCDs not due to CHD and/or ventricular arrhythmias, particularly among certain subsets of the population. The growing heterogeneity of the pathologies and mechanisms underlying SCD present major challenges for SCD prevention, which are magnified further by a frequent lack of recognition of the underlying cardiac condition prior to death. Multifaceted preventative approaches, which address risk factors in seemingly low risk and known high-risk populations will be required to decrease the burden of SCD. In this Compendium, we review the wide-ranging spectrum of epidemiology underlying SCD within both the general population and in high-risk subsets with established cardiac disease placing an emphasis on recent global trends, remaining uncertainties, and potential targeted preventive strategies.