Beta blocker therapy is associated with reduced depressive symptoms 12 months post percutaneous coronary intervention
Beta blocker therapy is associated with reduced depressive symptoms 12 months post percutaneous coronary intervention
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DOI：
10.1016/j.jad.2011.09.047
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发表时间：
2012-02-01
影响因子：
6.6
通讯作者：
van Domburg, Ron T.
中科院分区：
文献类型：
--
作者：
Battes, Linda C.;Pedersen, Susanne S.;van Domburg, Ron T.
背景：β受体阻滞剂治疗可能会引起抑郁症状，尽管目前的证据是相互矛盾的。我们研究了β受体阻滞剂治疗和抑郁症状之间的关联，在经皮冠状动脉介入治疗（PCI）患者的程度有一个剂量-反应关系β受体阻滞剂剂量和抑郁symptoms.Methods：PCI治疗的患者（N = 685）完成了抑郁量表的医院焦虑和抑郁量表1和12个月后PCI。有关β受体阻滞剂使用的类型和剂量的信息从病历中提取。结果：在所有患者中，68%（466/685）在基线时接受β受体阻滞剂治疗。在校正分析中，PCI术后1个月使用β受体阻滞剂（OR：0.82; 95% CI：0.53-1.26）与抑郁症状无显著相关性。PCI术后12个月，β受体阻滞剂的使用与抑郁症状之间存在显著相关性（OR：0.51; 95%CI：0.31 -0.84），β受体阻滞剂治疗与抑郁症状风险降低49%相关。β受体阻滞剂剂量与PCI术后12个月抑郁症状之间存在剂量反应关系。与低剂量相关的抑郁症状风险降低36%（OR：0.64：95% CI：037-1.10）和58%（OR：0.42; 95%CI：024-0.76）。结论：接受β受体阻滞剂治疗的患者在PCI后12个月不太可能出现抑郁症状，存在剂量-反应关系，较高剂量提供更显著的保护作用。(C)2011 Elsevier B. V.保留所有权利。
Background: Beta blocker therapy may induce depressive symptoms, although current evidence is conflicting. We examined the association between beta blocker therapy and depressive symptoms in percutaneous coronary intervention (PCI) patients and the extent to which there is a dose-response relationship between beta blocker dose and depressive symptoms.Methods: Patients treated with PCI (N = 685) completed the depression scale of the Hospital Anxiety and Depression Scale 1 and 12 months post PCI. Information about type and dose of beta blocker use was extracted from medical records.Results: Of all patients, 68% (466/685) were on beta blocker therapy at baseline. In adjusted analysis, beta blocker use at 1 month post PCI (OR: 0.82; 95% CI: 0.53-1.26) was not significantly associated with depressive symptoms. At 12 months post PCI, there was a significant relationship between beta blocker use and depressive symptoms (OR: 0.51; 95% CI: 031-0.84), with beta blocker therapy associated with a 49% risk reduction in depressive symptoms. There was a dose-response relationship between beta blocker dose and depressive symptoms 12 months post PCI. with the risk reduction in depressive symptoms in relation to a low dose being 36% (OR: 0.64:95% CI: 037-1.10) and 58% (OR: 0.42; 95% CI: 024-0.76) in relation to a high dose.Conclusions: Patients treated with beta blocker therapy were less likely to experience depressive symptoms 12 months post PCI, with there being a dose-response relationship with a higher dose providing a more pronounced protective effect. (C) 2011 Elsevier B.V. All rights reserved.