Histologic grading in soft‐tissue sarcomas. An analysis of 194 cases including agnor count and mast‐cell count
Histologic grading in soft‐tissue sarcomas. An analysis of 194 cases including agnor count and mast‐cell count
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194例软组织肉瘤的组织学分级，包括agnor计数和肥大细胞计数。
DOI：
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发表时间：
1993
影响因子：
6.4
通讯作者：
Kunio Matsumoto
中科院分区：
文献类型：
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作者：
Y. Tomita;K. Aozasa;A. Myoui;S. Kuratsu;A. Uchida;K. Ono;Kunio Matsumoto
为了建立一个新的STS的组织学分级系统，我们评估了组织学预后因素。为此，我们选择了194例STS患者：31例发生在上肢，63例发生在躯干，100例发生在下肢。所有患者均行手术治疗，化疗74例，放疗11例，化疗加放疗30例，无辅助治疗79例。评估的组织学因素包括有丝分裂计数、坏死程度、细胞性、细胞多形性、粘液样变化程度、硬化、非特异性组织学诊断、核仁组织区银染色反应产物计数（AgNOR）和肥大细胞计数。单因素分析显示，有丝分裂计数、坏死、细胞结构、细胞多形性、非特异性组织学分类、AgNOR计数和肥大细胞计数与预后显著相关。多因素分析显示，AgNOR计数、细胞数量和坏死是独立的预后因素。介绍了一种新的分级制度：低、中、高。各组间生存率差异有统计学意义；低、中、高分级组患者的5年生存率分别为87%、74%和35%。我们的研究结果表明，这种组织学分级系统可能有助于制定治疗决策。
In order to establish a new histologic grading system for STS, we evaluated histologic prognostic factors. For this purpose, we selected 194 patients with STS: 31 in the upper extremities, 63 in the trunk, and 100 in lower extremities. All the patients were treated by surgery, followed by chemotherapy in 74 cases, radiotherapy in 11, chemotherapy and radiotherapy in 30, or no adjuvant treatment in 79. Histologic factors evaluated were mitotic count, extent of necrosis, cellularity, cellular pleomorphism, extent of myxoid change, sclerosis, non‐specific histologic diagnosis, counting of reaction product in silver stain for nucleolar organizer regions (AgNOR) and mast‐cell counts. Univariate analysis revealed mitotic count, necrosis, cellularity, cellular pleomorphism, non‐specific histologic classification, AgNOR count and mast‐cell count to be significantly related to prognosis. Multivariate analysis revealed that AgNOR count, cellularity and necrosis were independent prognostic factors. A new grading system was introduced: low‐grade, intermediate‐grade and high‐grade. The survival between each group were significantly different; the 5‐year‐survival rate in patients of the low‐, intermediate‐ and high‐grade groups was 87%, 74% and 35% respectively. Our findings suggest that this histologic grading system may be useful for making therapeutic decisions.
软组织肉瘤的分级：坏死作为生存的决定因素。
DOI：
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发表时间：
1989
期刊：
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
影响因子：
--
作者：
Kulander,BG;Polissar,L;Yang,CY;Woods,JS
通讯作者：
Woods,JS