PRENATAL EXPOSURE TO MATERNAL AND PATERNAL DEPRESSIVE SYMPTOMS AND BRAIN MORPHOLOGY: A POPULATION-BASED PROSPECTIVE NEUROIMAGING STUDY IN YOUNG CHILDREN
PRENATAL EXPOSURE TO MATERNAL AND PATERNAL DEPRESSIVE SYMPTOMS AND BRAIN MORPHOLOGY: A POPULATION-BASED PROSPECTIVE NEUROIMAGING STUDY IN YOUNG CHILDREN
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DOI：
10.1002/da.22524
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发表时间：
2016-07-01
影响因子：
7.4
通讯作者：
White, Tonya J. H.
中科院分区：
文献类型：
--
作者：
El Marroun, Hanan;Tiemeier, Henning;White, Tonya J. H.
背景：产前抑郁症状与多种不良结局相关。以前，我们证明了产前抑郁症状与胎儿生长受损和1.5至6岁儿童行为问题增加有关。在这项前瞻性研究中，我们的目的是评估产前母亲抑郁症状在3年是否有长期的后果对大脑发育的一个队列中的儿童6-10岁。作为对比，父亲在怀孕期间的抑郁症状和脑形态学的关联进行了评估，作为一个标记的背景混淆，由于共享的遗传和环境的家庭因素。方法：采用简明症状自评量表对父母在妊娠期的抑郁症状进行评定。在大约8岁时，我们收集了结构神经影像学数据，使用皮质厚度，表面积和脑回作为结果（n = 654）。结果如下：我们发现，在怀孕期间暴露于产前母亲抑郁症状与左半球较薄的上级额叶皮层有关。此外，产前母亲抑郁症状与左半球较大的尾中额区有关。3岁时母亲抑郁症状与左右半球的皮质厚度、表面积或脑回化无关。未观察到父亲抑郁症状对脑形态的影响。结论：产前母亲抑郁症状与儿童脑形态学的差异有关。在怀孕期间预防、识别和治疗抑郁症状非常重要，因为它可能对儿童大脑发育产生长期影响。(C)2016 Wiley Periodicals，Inc.
Background: Prenatal depressive symptoms have been associated with multiple adverse outcomes. Previously, we demonstrated that prenatal depressive symptoms were associated with impaired growth of the fetus and increased behavioral problems in children aged between 1.5 and 6 years. In this prospective study, we aimed to assess whether prenatal maternal depressive symptoms at 3 years have long-term consequences on brain development in a cohort of children aged 6-10 years. As a contrast, the association of paternal depressive symptoms during pregnancy and brain morphology was assessed to serve as a marker of background confounding due to shared genetic and environmental family factors. Methods: We assessed parental depressive symptoms during pregnancy with the Brief Symptom Inventory. At approximately 8 years of age, we collected structural neuroimaging data, using cortical thickness, surface area, and gyrification as outcomes (n = 654). Results: We found that exposure to prenatal maternal depressive symptoms during pregnancy was associated with a thinner superior frontal cortex in the left hemisphere. Additionally, prenatal maternal depressive symptoms were related to larger caudal middle frontal area in the left hemisphere. Maternal depressive symptoms at 3 years were not associated with cortical thickness, surface area, or gyrification in the left and right hemispheres. No effects of paternal depressive symptoms on brain morphology were observed. Conclusions: Prenatal maternal depressive symptoms were associated with differences in brain morphology in children. It is important to prevent, identify, and treat depressive symptoms during pregnancy as it may have long-term consequences on child brain development. (C) 2016 Wiley Periodicals, Inc.