Cytogenetic Surveillance of Industrial Populations
Cytogenetic Surveillance of Industrial Populations
复制标题
工业人群的细胞遗传学监测
DOI：
10.1007/978-1-4684-0892-8_9
复制
发表时间：
1976
影响因子：
2
通讯作者：
D. Picciano
中科院分区：
文献类型：
--
作者：
D. J. Kilian;D. Picciano
It is difficult to demonstrate the precise etiology of chromosomal damage in man because of the great variety and environmental ubiquity of the agents—drugs, chemicals, viruses, and physical forces—known or suspected to cause chromosomal breakage and consequent aberrations. While the researcher has findings available from a vast array of tests, ranging from in vitro bacterial experiments and sophisticated chemical studies to large-scale utilization of laboratory animals, valid extrapolation of these findings to man is often impossible. Even the demonstration of experimentally mutagenic compounds, or their metabolites, to be present in human tissue does not give conclusive evidence of either damage or damage-repair. Specifically human findings are available from a limited number of accidental or clinical exposures to chromosome-breaking, or clastogenic,(1) agents, but these data are conflicting, fragmentary, and difficult to approximate to the workaday world.
