Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population
Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population
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DOI：
10.1016/j.neulet.2007.02.055
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发表时间：
2007-05-07
影响因子：
2.5
通讯作者：
Arinami, Tadao
中科院分区：
文献类型：
--
作者：
Koga, Minori;Ishiguro, Hiroki;Arinami, Tadao
蛋白质 zeta-1 (FEZ1) 的纤维束和延伸是 Disrupted-In-Schizophrenia 1 (DISC1) 的结合伴侣。由于 DISC1 基因被证明是苏格兰家庭精神病的致病基因，因此 FEZ1 基因很可能在精神疾病中具有重要意义。之前的一项关联研究分析了日本精神分裂症患者和对照受试者的 FEZ1 基因多态性，发现 Asp123Glu 多态性与精神分裂症存在显着关联。在本研究中，我们检查了 FEZ1 基因中的两个多态性标记 rs559668 和 rs597570 (Asp123Glu)，以证实 1920 名日本精神分裂症患者和 1920 名对照受试者之间的关联。检测关联的功效大于 0.98。然而，我们没有检测到这两个单核苷酸多态性与精神分裂症的基因型关联（分别为 p = 1 和 0.79）。我们得出的结论是，FEZ1 基因的错义突变 Asp123Glu 不太可能在精神分裂症的遗传易感性中发挥重要作用。 (c) 2007 Elsevier Ireland Ltd. 保留所有权利。
Fasciculation and elongation of protein zeta-1 (FEZ1) is a binding partner of Disrupted-In-Schizophrenia 1 (DISC1). Because the DISC1 gene is shown to be a causative gene for psychosis in a Scottish family, the FEZ1 gene may well have importance in mental disease. A previous association study that analyzed polymorphisms of the FEZ1 gene in Japanese patients with schizophrenia and control subjects found significant association of the Asp123Glu polymorphism with schizophrenia. In the present study, we examined two polymorphic markers, rs559668 and rs597570 (Asp123Glu), in the FEZ1 gene to confirm the association in 1920 Japanese patients with schizophrenia and 1920 control subjects. The power to detect an association was more than 0.98. However, we did not detect genotypic associations of either of these two single nucleotide polymorphisms with schizophrenia (p = 1 and 0.79, respectively). We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia. (c) 2007 Elsevier Ireland Ltd. All rights reserved.