Palladium-Catalyzed Insertion of α-Diazoesters into Vinyl Halides To Generate α,β-Unsaturated γ-Amino Esters
Palladium-Catalyzed Insertion of α-Diazoesters into Vinyl Halides To Generate α,β-Unsaturated γ-Amino Esters
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DOI：
10.1002/anie.200805483
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Van Vranken, David L.
中科院分区：
文献类型：
--
作者：
Kudirka, Romas;Devine, Sean K. J.;Van Vranken, David L.
就像1、2、3一样简单：钯催化的三组分偶联在一个步骤中生成α，β-不饱和γ-氨基酸（见方案）。该反应被认为涉及乙烯基取代基迁移到高度亲电的钯卡宾。与以前的合成方法不同，这种合成提供了获得具有非天然侧链的γ-氨基酸的途径。
As easy as 1, 2, 3: A palladium‐catalyzed three‐component coupling generates α,β‐unsaturated γ‐amino acids in a single step (see scheme). The reaction is believed to involve migration of a vinyl substituent to a highly electrophilic palladium carbene. Unlike previous synthetic approaches, this synthesis provides access to γ‐amino acids with non‐natural side chains.