Contrasting Medical and Legal Standards of Evidence: A Precision Medicine Case Study.
Contrasting Medical and Legal Standards of Evidence: A Precision Medicine Case Study.
复制标题
DOI：
10.1177/1073110516644210
复制
发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Campos-Outcalt D
中科院分区：
文献类型：
--
作者：
Marchant GE;Scheckel K;Campos-Outcalt D
随着医疗保健系统过渡到根据个体患者的基因特征量身定做临床护理的精准医学方法，提供者对新技术的临床吸收与法律系统在应用这些技术时对护理标准的期望之间存在潜在的矛盾。我们通过比较医生和法院在确定建议对口服抗凝药物华法林的患者进行药物遗传学测试的义务时可能依赖的证据类型来检查这种紧张关系。有大量不一致的证据和支持和反对这种测试的因素，但医生和法院可能会以不同的方式权衡这一证据。对医疗事故风险的潜在影响进行了评估和讨论。
As the health care system transitions to a precision medicine approach that tailors clinical care to the genetic profile of the individual patient, there is a potential tension between the clinical uptake of new technologies by providers and the legal system’s expectation of the standard of care in applying such technologies. We examine this tension by comparing the type of evidence that physicians and courts are likely to rely on in determining a duty to recommend pharmacogenetic testing of patients prescribed the oral anti-coagulant drug warfarin. There is a large body of inconsistent evidence and factors for and against such testing, but physicians and courts are likely to weigh this evidence differently. The potential implications for medical malpractice risk are evaluated and discussed.
登录
查看更多内容
DOI：
10.1056/nejmoa1310669
发表时间：
2013-12-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kimmel SE;French B;Kasner SE;Johnson JA;Anderson JL;Gage BF;Rosenberg YD;Eby CS;Madigan RA;McBane RB;Abdel-Rahman SZ;Stevens SM;Yale S;Mohler ER 3rd;Fang MC;Shah V;Horenstein RB;Limdi NA;Muldowney JA 3rd;Gujral J;Delafontaine P;Desnick RJ;Ortel TL;Billett HH;Pendleton RC;Geller NL;Halperin JL;Goldhaber SZ;Caldwell MD;Califf RM;Ellenberg JH;COAG Investigators
通讯作者：
COAG Investigators
影响因子：
8.3
作者：
Dowlatshahi, Dar;Butcher, Kenneth S.;Coutts, Shelagh B.
通讯作者：
Coutts, Shelagh B.
影响因子：
39.2
作者：
Eckman, Mark H.;Rosand, Jonathan;Gage, Brian F.
通讯作者：
Gage, Brian F.
影响因子：
37.8
作者：
Anderson, Jeffrey L.;Horne, Benjamin D.;Carlquist, John F.
通讯作者：
Carlquist, John F.
影响因子：
9.3
作者：
Johnson, Julie A.;Cavallari, Larisa H.
通讯作者：
Cavallari, Larisa H.