SYNTHESIS OF UNSYMMETRICAL 1,4-DIKETONES BY THE CERIC AMMONIUM-NITRATE PROMOTED CROSS-COUPLING OF TRIMETHYLSILYL ENOL ETHERS
SYNTHESIS OF UNSYMMETRICAL 1,4-DIKETONES BY THE CERIC AMMONIUM-NITRATE PROMOTED CROSS-COUPLING OF TRIMETHYLSILYL ENOL ETHERS
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DOI：
10.1016/s0040-4039(01)80489-5
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发表时间：
1989-01-01
影响因子：
1.8
通讯作者：
RUZZICONI, R
中科院分区：
文献类型：
--
作者：
BACIOCCHI, E;CASU, A;RUZZICONI, R
通过硝酸铈铵氧化偶联1，2-二取代和1-取代的三甲基硅烯醇醚，以良好的产率（60-80%）制备了不对称的1，4-二酮。4-因为这些化合物广泛用作合成呋喃和许多具有生物活性的天然产物和生物活性产物的关键中间体，环戊酮环，如洋茉莉素和茉莉素。羰基化合物与具有烯醇双键的体系（例如乙酸异丙烯酯）的氧化加成是制备1，4-二酮的有用方法，
Unsmtrical 1, 4-diketones are prepared in good yields (60-80%) by cerium (IV) am-ronium nitrate oxidative cross-coupling between 1, 2-disubstituted and l-substituted trimathylsilyl enol ethers.There is continuing interest in the synthesis of 1, 4-diketones' since these compounds are extensively used as key intermediates in the synthesis of furans and many natural and biologically active products possessing the cyclopentanone ring, such as prostaqlandins and jasmonoids. The oxidative addition of car-bony1 compounds to systems with an enolic double bond (eg, isopropenyl acetate) is a useful approach to 1, 4-diketones,