Correspondence Between Stimulus Encoding- and Maintenance-Related Neural Processes Underlies Successful Working Memory
Correspondence Between Stimulus Encoding- and Maintenance-Related Neural Processes Underlies Successful Working Memory
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DOI：
10.1093/cercor/bhs339
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发表时间：
2014-03-01
期刊：
影响因子：
3.7
通讯作者：
D'Esposito, Mark
中科院分区：
文献类型：
--
作者：
Cohen, Jessica R.;Sreenivasan, Kartik K.;D'Esposito, Mark
在工作记忆(WM)中主动保持信息的能力对目标导向行为至关重要，但这一过程背后的机制仍然难以捉摸。我们假设，成功的WM依赖于与刺激编码相关的神经过程与与维持相关的神经过程之间的对应关系。使用功能磁共振成像，我们确定了刺激编码过程中的区域活动和区域间连通性，并在这些刺激不再存在时保持这些刺激。我们比较了这些神经过程在编码和维持时期的对应关系与WM性能。更重要的是，编码和维持在1)外侧前额叶皮质(PFC)的区域活动和2)外侧PFC和纹外皮质之间的连接之间的更大的一致性与提高的表现相关。这些发现表明，在编码和维持过程中神经过程的保守性支持了工作记忆表征的完整性。
The ability to actively maintain information in working memory (WM) is vital for goal-directed behavior, but the mechanisms underlying this process remain elusive. We hypothesized that successful WM relies upon a correspondence between the neural processes associated with stimulus encoding and the neural processes associated with maintenance. Using functional magnetic resonance imaging, we identified regional activity and inter-regional connectivity during stimulus encoding and the maintenance of those stimuli when they were no longer present. We compared correspondence in these neural processes across encoding and maintenance epochs with WM performance. Critically, greater correspondence between encoding and maintenance in 1) regional activity in the lateral prefrontal cortex (PFC) and 2) connectivity between lateral PFC and extrastriate cortex was associated with increased performance. These findings suggest that the conservation of neural processes across encoding and maintenance supports the integrity of representations in WM.