Epidermal growth factor receptor is indispensable for c-Fos expression and protein synthesis by angiotensin II.
Epidermal growth factor receptor is indispensable for c-Fos expression and protein synthesis by angiotensin II.
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DOI：
10.1016/s0014-2999(99)00357-x
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发表时间：
1999-07
影响因子：
5
通讯作者：
S. Eguchi;H. Iwasaki;Y. Hirata;G. D. Frank;E. Motley;T. Yamakawa;K. Numaguchi;T. Inagami
中科院分区：
文献类型：
--
作者：
S. Eguchi;H. Iwasaki;Y. Hirata;G. D. Frank;E. Motley;T. Yamakawa;K. Numaguchi;T. Inagami
We have reported that angiotensin II induces the epidermal growth factor (EGF) receptor transactivation leading to extracellular signal-regulated kinase (ERK) activation in rat vascular smooth muscle cells. Here, we report that the EGF receptor kinase inhibitor AG1478 and the ERK kinase inhibitor PD98059 markedly inhibited angiotensin II-induced c-Fos expression and protein synthesis but not c-Jun expression in these cells. These data suggest that the EGF receptor transactivation and subsequent ERK activation are indispensable for angiotensin II-mediated growth promotion of vascular smooth muscle cells providing a new mechanistic insight whereby angiotensin II contributes abnormal vascular remodeling.
