New limonoids from Coptidis Rhizoma–Euodiae Fructus couple
New limonoids from Coptidis Rhizoma–Euodiae Fructus couple
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DOI：
10.1080/10286020.2014.881355
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发表时间：
2014-03
影响因子：
1.7
通讯作者：
Ping-Ting Qian;Hong Jin;Xiu-wei Yang
中科院分区：
文献类型：
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作者：
Ping-Ting Qian;Hong Jin;Xiu-wei Yang
从杜仲-杜仲对中分离得到一对新的柠檬苦素类化合物，分别命名为eudirutaecins A（1a）和B（1B），以及两个新的单一化合物evodirutaenin A（2）和shihulimonin A1（5），以及已知的柠檬苦素类化合物rutaevin（3），limonin（4），12α-hydroxyrutaevin（6），生物碱rutaecarpine和evodiamine。通过光谱分析和量子化学计算方法对化合物的结构进行了鉴定，并对6个柠檬苦素类化合物进行了NCI-N87和Caco-2细胞毒活性评价。
A pair of inseparable new limonoids, named euodirutaecins A (1a) and B (1b), were isolated from the Coptidis Rhizoma–Euodiae Fructus couple, together with two new single compounds evodirutaenin A (2) and shihulimonin A1 (5), and the known limonoids rutaevin (3), limonin (4), 12α-hydroxyrutaevin (6), and alkaloids rutaecarpine and evodiamine. Structures of these compounds were identified by spectral analyses and quantum chemical computational method, and the six limonoids were also evaluated for cytotoxicities against NCI-N87 and Caco-2 cell lines.