Cognitive and motor reaction times in obstructive sleep apnea syndrome: A study based on computerized measures
Cognitive and motor reaction times in obstructive sleep apnea syndrome: A study based on computerized measures
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DOI：
10.1016/j.bandc.2017.07.002
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发表时间：
2017-10-01
影响因子：
2.5
通讯作者：
Mondini, Sara
中科院分区：
文献类型：
--
作者：
Devita, Maria;Montemurro, Sonia;Mondini, Sara
阻塞性睡眠呼吸暂停综合征（OSAS）主要与执行功能障碍有关。虽然OSAS患者的延迟反应时间（RTs）有报道，但处理速度的敏感性尚未得到充分评估。本研究提出了敏感和可靠的方法来澄清信息处理速度的不同组成部分，即认知和运动反应，是否在OSAS中受到同样的损害。33例OSAS患者与30例健康对照进行比较。MoCA测试用于评估参与者的整体神经心理状况。认知和运动反应时间是用一个检测器来测量的，它可以区分刺激编码、决策处理和选择适当的运动反应。Logistic回归模型强调MoCA测试和运动RTs是区分患者和健康参与者的最佳预测因子。结果支持OSAS患者认知能力轻微下降的假设，并确定了反应的运动成分显著减慢。可以假设，较慢的运动反应是导致这些患者整体认知概况的原因。随着年龄的增长，运动运动和RTs通常会受损，缺氧可能会首先损害RTs的运动成分，从而加速衰老过程。
Obstructive Sleep Apnea Syndrome (OSAS) is mainly associated with executive dysfunction. Although delayed reaction times (RTs) in patients with OSAS have been reported, sensitivity of processing speed has not been adequately assessed. This study suggests sensitive and reliable measures to clarify whether different components of information processing speed, i.e. cognitive and motor responses, are equally impaired in OSAS. Thirty-three patients with OSAS were compared with thirty healthy controls. The MoCA test was administered to assess participants' global neuropsychological profile. Cognitive and motor reaction times were measured using a detector panel which allows to distinguish between stimulus encoding, decision processing, and selection of the appropriate motor response. Logistic regression models highlighted both MoCA test and motor RTs as the best predictors differentiating patients from healthy participants.Results support the hypothesis of a slight decline in the cognitive profile of patients with OSAS and identify significant slowing down in the motor component of responses. It could be hypothesized that slower motor responsiveness is the cause of the global cognitive profile of these patients. With aging, motor movements and RTs usually become impaired and hypoxia might accelerate the aging process by compromising first of all the motor component of RTs.