Cholinergic agonist carbachol enables associative long-term potentiation in piriform cortex slices
Cholinergic agonist carbachol enables associative long-term potentiation in piriform cortex slices
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DOI：
10.1152/jn.1998.80.5.2467
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发表时间：
1998-11-01
影响因子：
2.5
通讯作者：
Hasselmo, ME
中科院分区：
文献类型：
--
作者：
Patil, MM;Linster, C;Hasselmo, ME
梨状（嗅）皮层锥体细胞既接受嗅球传入输入，也接受梨状皮层和其他皮层区域的内在关联输入。这两种功能不同的输入终止于梨状皮层la层和Ib层锥体细胞相邻的顶端树突节。盆浴应用胆碱能激动剂的研究表明，通过刺激联合纤维引起的抑制性突触后电位（IPSPs）的快速成分受到抑制。先前已经证明，在阻断快速的-氨基丁酸-a介导的IPSP后，两种纤维系统的共激活可以诱导LTP的结合形式。在本报告中，我们证明了在胆碱能激动剂碳醇存在的情况下，传入纤维和内禀纤维的共同激活可以诱导联想形式的长期增强。
Pyramidal cells in piriform (olfactory) cortex receive afferent input from the olfactory bulb as well as intrinsic association input from piriform cortex and other cortical areas. These two functionally distinct inputs terminate on adjacent apical dendritic segments of the pyramidal cells located in layer la and layer Ib of piriform cortex. Studies with bath-applied cholinergic agonists have shown suppression of the fast component of the inhibitory postsynaptic potentials (IPSPs) evoked by stimulation of the association fibers. It was previously demonstrated that an associative form of LTP can be induced by coactivation of the two fiber systems after blockade of the fast, gamma-aminobutyric acid-A-mediated IPSP. In this report, we demonstrate that an associative form of long-term potentiation can be induced by coactivation of afferent and intrinsic fibers in the presence of the cholinergic agonist carbachol.