Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans.
Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans.
复制标题
二氧化氮暴露对人类支气管肺泡灌洗蛋白的影响。
DOI：
10.1165/ajrcmb/1.6.499
复制
发表时间：
1989
影响因子：
6.4
通讯作者：
Utell,MJ
中科院分区：
文献类型：
--
作者：
Frampton,MW;Finkelstein,JN;RobertsJr,NJ;Smeglin,AM;Morrow,PE;Utell,MJ
二氧化氮（NO2）是一种特别重要的氧化性污染物，因为它存在于室外和室内大气中（1，2）。室内NO2水平已被观察到超过室外水平的家庭与未通风的燃烧源，达到峰值超过2.0 ppm（3）。短暂暴露于高水平的NO2可导致急性炎症反应和由于上皮渗透性增加而导致的肺水肿（4），这一事实导致了对低水平暴露影响的担忧。动物长期暴露于接近环境范围的水平，导致上皮损伤、II型细胞增殖和肺泡巨噬细胞改变（5，6），这一担忧是合理的。
Nitrogen dioxide (NO2) is an oxidant pollutant of particular importance because of its presence in both outdoor and indoor atmospheres (1, 2). Indoor NO2 levels have been observed to exceed outdoor levels in homes with unvented sources of combustion, reaching peaks in excess of 2.0 ppm (3). The fact that brief exposure to a high level of NO2 can result in an acute inflammatory response and pulmonary edema due to increased epithelial permeability (4) has led to concern regarding the effects of lower level exposures. Chronic exposures of animals to levels near the ambient range have resulted in epithelial injury, proliferation of type II cells, and alterations in alveolar macrophages (5, 6), lending justification for this concern.