Azole susceptibility and resistance in Candida dubliniensis.
Azole susceptibility and resistance in Candida dubliniensis.
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都柏林念珠菌对唑的敏感性和耐药性。
DOI：
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发表时间：
2005
影响因子：
3.9
通讯作者：
D. Sullivan
中科院分区：
文献类型：
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作者：
E. Pinjon;G. Moran;D. C. Coleman;D. Sullivan
都柏林念珠菌是最近发现的一种与白色念珠菌具有许多表型特征的致病性酵母菌。它主要与hiv感染者的口腔定植和感染有关。分离的dubliniensis对常用的唑类抗真菌药普遍敏感；然而，在临床分离株中已观察到耐药性，并可通过体外暴露诱导。dubliniensis耐唑的分子机制包括药物外排增加、靶酶的修饰和麦角甾醇生物合成途径的改变。
Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. Isolates of C. dubliniensis are generally susceptible to commonly used azole antifungal agents; however, resistance has been observed in clinical isolates and can be induced by in vitro exposure. Molecular mechanisms of azole resistance in C. dubliniensis include increased drug efflux, modifications of the target enzyme and alterations in the ergosterol biosynthetic pathway.
白色念珠菌 ERG3（C-5 甾醇去饱和酶基因）的克隆、测序、表达和等位基因序列多样性。
影响因子：
3.5
作者：
Miyazaki,Y;Geber,A;Miyazaki,H;Falconer,D;Parkinson,T;Hitchcock,C;Grimberg,B;Nyswaner,K;Bennett,JE
通讯作者：
Bennett,JE