Moderate noise trauma in juvenile cats results in profound cortical topographic map changes in adulthood
Moderate noise trauma in juvenile cats results in profound cortical topographic map changes in adulthood
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DOI：
10.1016/s0378-5955(00)00024-1
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发表时间：
2000-04-01
期刊：
影响因子：
2.8
通讯作者：
Komiya, H
中科院分区：
文献类型：
--
作者：
Eggermont, JJ;Komiya, H
据报道，在新生儿严重药物性听力损失、进行性高频听力损失以及成年动物耳蜗机械性损伤后，皮质地形图会发生变化。本研究表明，5 周大的小猫暴露在 6 kHz 的响亮音调中会产生轻度至中度高频听力损失，从而引起听觉皮层频率图的深刻重组。在重组的皮质区域，频率调谐曲线具有正常的清晰度，接近正常阈值。抑制调谐曲线带宽与对照动物相似。皮质重组部分的自发活动显着增加。相反，在正常部分和重组部分中，不同电极上记录的单元自发活动的互相关强度是相同的。受创伤的猫的最小首次尖峰潜伏期显着增加，主要是采样区域背侧的单位。由于大多数其他神经反应特性在皮质重组部分中是正常的，因此皮质下地形图的变化可能涉及产生改变的皮质地形图。 (C) 2000 Elsevier Science B.V. 保留所有权利。
Cortical topographic map changes have been reported after profound drug-induced hearing loss in neonates, after progressive high-frequency hearing loss, and after mechanically induced lesions in the cochlea of adult animals. The present study demonstrates that exposure of 5-week-old kittens to a loud 6 kHz tone, producing mild to moderate high-frequency hearing loss, induces a profound reorganization of the frequency map in auditory cortex. In the reorganized cortical region, the frequency-tuning curves were of normal sharpness with near normal thresholds. Inhibitory tuning curve bandwidths were similar to those in control animals. Spontaneous activity in the reorganized part of the cortex was significantly increased. In contrast, the strength of the crosscorrelation of the spontaneous activity of units recorded on different electrodes was the same in the normal and reorganized part. Minimum first-spike latency was significantly increased in trauma cats, largely for units at the dorsal side of the sampled region. Because most other neural response properties are normal in the reorganized part of cortex, sub-cortical topographic mag changes are likely involved in producing the altered cortical topographic maps. (C) 2000 Elsevier Science B.V. All rights reserved.