High-Density Substrate Mapping in Brugada Syndrome Combined Role of Conduction and Repolarization Heterogeneities in Arrhythmogenesis
High-Density Substrate Mapping in Brugada Syndrome Combined Role of Conduction and Repolarization Heterogeneities in Arrhythmogenesis
复制标题
DOI：
10.1161/circulationaha.108.771401
复制
发表时间：
2009-07-14
期刊：
影响因子：
37.8
通讯作者：
McKenna, W. J.
中科院分区：
文献类型：
--
作者：
Lambiase, P. D.;Ahmed, A. K.;McKenna, W. J.
背景-Brugada综合征（BS）有两种主要机制：（1）右心室（RV）传导延迟和（2）RV心外膜下动作电位缩短。这在体内高密度映射研究评估的传导和复极属性的RV在BS subjects.Methods和Results-A非接触式映射阵列被定位在RV的18个BS患者和20个控制。使用标准的S-1-S-2协议，局部激活时间和激活恢复间隔的恢复曲线被构建以确定局部最大恢复斜率。BS患者的RV流出道前外侧游离壁存在显著的区域性传导延迟。该区域延迟的平均增加是对照组的3倍（P=0
Background-Two principal mechanisms are thought to be responsible for Brugada syndrome (BS): (1) right ventricular (RV) conduction delay and (2) RV subepicardial action potential shortening. This in vivo high-density mapping study evaluated the conduction and repolarization properties of the RV in BS subjects.Methods and Results-A noncontact mapping array was positioned in the RV of 18 BS patients and 20 controls. Using a standard S-1-S-2 protocol, restitution curves of local activation time and activation recovery interval were constructed to determine local maximal restitution slopes. Significant regional conduction delays in the anterolateral free wall of the RV outflow tract of BS patients were identified. The mean increase in delay was 3-fold greater in this region than in control (P=0