Immunolocalization of sperm protein 17 in human testis and ejaculated spermatozoa
Immunolocalization of sperm protein 17 in human testis and ejaculated spermatozoa
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DOI：
10.1177/002215540305100916
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发表时间：
2003-09-01
影响因子：
3.2
通讯作者：
Dioguardi, N
中科院分区：
文献类型：
--
作者：
Grizzi, F;Chiriva-Internati, M;Dioguardi, N
精子蛋白17(Sp17)是一种高度保守的哺乳动物蛋白，其主要功能尚不清楚。人睾丸免疫组织化学(IHC)显示Sp17在部分精母细胞中存在，在精子细胞中大量存在。所有精原细胞、支持细胞和间质细胞均呈Sp17免疫阳性，而部分间质细胞呈免疫阳性。IHC在射出的精子中识别出两个不同的群体(Sp17免疫阳性或不阳性)。尽管有必要澄清为什么一些射出的精子不包含Sp17，但它的分布表明该蛋白可能与生发细胞分化的某些阶段有关。
Sperm protein 17 (Sp17) is a highly conserved mammalian protein whose primary function is still poorly understood. Immunohistochemistry (IHC) in the human testis reveals the presence of Sp17 in some spermatocytes and abundantly in spermatids. All spermatogonia, Sertoli cells, and Leydig cells appear to be immunonegative for Sp17, whereas some interstitial cells are immunopositive. IHC recognized two distinct populations (immunopositive or not for Sp17) in the ejaculated spermatozoa. Although it will be necessary to clarify why some ejaculated spermatozoa do not contain Sp17, its distribution suggests that this protein may be associated with some phases of germinal cell differentiation.