Infrastructure to support ultra high throughput biodosimetry screening after a radiological event
Infrastructure to support ultra high throughput biodosimetry screening after a radiological event
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DOI：
10.3109/09553002.2011.583317
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发表时间：
2011-08-01
影响因子：
2.6
通讯作者：
Brenner, David J.
中科院分区：
文献类型：
--
作者：
Garty, Guy;Karam, Andrew;Brenner, David J.
目的：在大规模放射事件发生后，迫切需要在几天内评估数万或数十万人所受到的辐射剂量。这是为了分诊，在资源有限的情况下防止治疗地点不堪重负，并促进剂量依赖性治疗决策。此外，还有心理社会方面的考虑，因为积极保证最低限度的接触可能是消除大规模恐慌的有效方法，此外还有长期考虑，以促进以后对癌症和其他长期疾病风险的研究。材料和方法：正如本期其他部分所述，我们正在开发一种快速自动生物剂量测定工具（RABiT）。RABiT允许每天对数千份血液样本进行高通量分析，提供剂量估计，可用于支持临床分诊和治疗决策。结果：RABiT的发展促使我们考虑将这样一个系统纳入大城市地区现有应急响应方案的后勤。我们在这里提出了一个观点，即如何将一个或多个集中式生物剂量测定读数装置纳入基础设施，在受影响的城市或地区的许多分布地点采集手指刺血样本并将其运送到集中地点。结论：高通量生物剂量测定系统提供了对大量人群进行生物剂量测定评估的机会。随着这些系统达到高度成熟，需要调整应急响应方案，以利用这些强大的工具。这可以在当前场景的框架内相对容易地完成。
Purpose: After a large-scale radiological event, there will be a pressing need to assess, within a few days, the radiation doses received by tens or hundreds of thousands of individuals. This is for triage, to prevent treatment locations from being overwhelmed, in what is sure to be a resource limited scenario, as well as to facilitate dose-dependent treatment decisions. In addition there are psycho-social considerations, in that active reassurance of minimal exposure is a potentially effective antidote to mass panic, as well as long-term considerations, to facilitate later studies of cancer and other long-term disease risks.Materials and methods: As described elsewhere in this issue, we are developing a Rapid Automated Biodosimetry Tool (RABiT). The RABiT allows high throughput analysis of thousands of blood samples per day, providing a dose estimate that can be used to support clinical triage and treatment decisions.Results: Development of the RABiT has motivated us to consider the logistics of incorporating such a system into the existing emergency response scenarios of a large metropolitan area. We present here a view of how one or more centralized biodosimetry readout devices might be incorporated into an infrastructure in which fingerstick blood samples are taken at many distributed locations within an affected city or region and transported to centralized locations.Conclusions: High throughput biodosimetry systems offer the opportunity to perform biodosimetric assessments on a large number of persons. As such systems reach a high level of maturity, emergency response scenarios will need to be tweaked to make use of these powerful tools. This can be done relatively easily within the framework of current scenarios.