Self-recognition and the role of fetal microchimerism
Self-recognition and the role of fetal microchimerism
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DOI：
10.1016/j.beem.2004.03.002
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发表时间：
2004-06-01
影响因子：
7.4
通讯作者：
Davies, TF
中科院分区：
文献类型：
--
作者：
Ando, T;Davies, TF
众所周知，自身免疫性甲状腺疾病 (AITD) 的病程和严重程度受妊娠影响，妊娠期间疾病抑制和产后疾病发生或恶化就证明了这一点。 AITD 还会影响生育能力和妊娠结局，胎儿流产率增加就证明了这一点。然而，这种影响的确切机制尚未完全了解。在这里，我们回顾了被认为在 AITD 中活跃的自我识别机制，并纳入了有关胎儿微嵌合现象（怀孕期间和怀孕后将父亲抗原暴露给母亲）潜在作用的最新信息。
The course and severity of the autoimmune thyroid diseases (AITD) is known to be influenced by pregnancy as evidenced by disease suppression during pregnancy and initiation, or exacerbation, of disease postpartum. AITD is also known to affect both fertility and pregnancy outcome as evidenced by increased fetal loss. However, the precise mechanisms of this influence have not been fully understood. Here we have reviewed the mechanisms of self-recognition thought to be active in AITD and we have included recent information on the potential role of fetal microchimerism (exposure of paternal antigen to the mother during and after pregnancy).