CORTISOL HYPERSECRETION IN DEPRESSED SCHOOL-AGED CHILDREN AND ADOLESCENTS
CORTISOL HYPERSECRETION IN DEPRESSED SCHOOL-AGED CHILDREN AND ADOLESCENTS
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DOI：
10.1016/0165-1781(91)90060-3
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发表时间：
1991-06-01
影响因子：
11.3
通讯作者：
ALTHAM, P
中科院分区：
文献类型：
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作者：
GOODYER, I;HERBERT, J;ALTHAM, P
一项前瞻性纵向研究已进行，以确定患有重度抑郁症的儿童（n = 10）的皮质醇分泌模式。在 24 小时内，当受试者情绪低落时，每隔 4 小时收集一次唾液皮质醇样本，当他们康复时，再次收集唾液皮质醇样本。组间比较表明，与康复期间相比，患病期间平均皮质醇输出量显着增加。在测量的 6 个时间点中，这种差异仅发生在 3 个时间点（午夜、凌晨 4 点、上午 8 点）。并非所有病例都表现出分泌过多，但当存在分泌过多时，会出现在症状更严重的病例中。此外，处于抑郁状态的个体与恢复状态的个体之间存在显着差异。在某些（但并非全部）病例中，分泌过多似乎与昼夜节律的显着改变有关。抑郁状态下皮质醇反应程度和 24 小时内的曲线形状值得进一步研究，并且可能对该年龄组重性抑郁的病程和结果产生影响。
A prospective longitudinal study has been carried out to determine the secretory pattern of cortisol in children (n = 10) with major depressive disorder. Salivary cortisol samples were collected at 4-hourly intervals over 24 hours when the subjects were depressed and again when they were recovered. Group comparison indicated that significant increases in mean cortisol output occurred during illness as compared with recovery. This difference occurred only at three points (midnight, 4 a.m., 8 a.m.) of six measured. Not all cases were showed hypersecretion, but when hypersecretion was present, it occurred in cases with more severe symptoms. In addition, marked differences existed within individuals in the depressed state vs. the recovered state. Hypersecretion appeared to be associated with a significant alteration in diurnal rhythm in some, but not all, cases. The degree of cortisol responsivity and the shape of the curve over 24 hours during the depressed state deserve further investigation and may have implications for the course and outcome of major depression in this age group.