Acute toxicity and health effect of perfluoroisobutyronitrile on mice: a promising substitute gas-insulating medium to SF(6).
Acute toxicity and health effect of perfluoroisobutyronitrile on mice: a promising substitute gas-insulating medium to SF(6).
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全氟异丁腈对小鼠的急性毒性和健康影响：一种有前途的 SF(6) 气体绝缘替代介质。
DOI：
10.1080/10934529.2020.1830654
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Xiao Song
中科院分区：
文献类型：
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作者：
Zhang Xiaoxing;Ye Fanchao;Li Yi;Tian Shuangshuang;Xie Baojuan;Gao Yadong;Xiao Song
全氟异丁腈（C4F7N）是一种新型环保气体绝缘介质，有望取代电力工业中使用的大部分温室气体六氟化硫（SF6）。为了保证工程应用的安全性，需要对C4F7N混合气体的急性吸入毒性进行深入评价。本文通过4h急性吸入毒性试验、血液学测定和组织病理学检查，揭示了C4 F7 N暴露后雄性和雌性小鼠的性别差异以及存活小鼠的生理恢复特征。并对C_4F_7N对小鼠和大鼠的毒性进行了比较分析。C_4F_7N对雌雄小鼠的LC_（50）分别为1175ppm（4h）、1380ppm（4h），雌性小鼠对C_4F_7N的耐受性较强。暴露于1000 ppm C4F7N 4 h的小鼠可存活，并在14天观察期后恢复正常状态，无不可逆损伤。C_4F_7N对大鼠的毒性作用持续时间较小鼠长。相关研究结果系统地揭示了C4F7N的急性吸入毒性，为吸入安全防护和工程应用提供了依据。
Perfluoroisobutyronitrile (C4F7N) is a new eco-friendly gas insulation medium that has potential to replace the most greenhouse gas sulfur hexafluoride (SF6) used in power industry. In order to ensure the engineering application safety, an in-depth assessment of the acute inhalation toxicity of C4F7N gas mixture is required. This article revealed gender differences in male and female mice after exposure to C4F7N and the physiological recovery characteristics of surviving mice by means of 4 h acute inhalation toxicity tests, hematological determinations and histopathological examination. Comparative analysis on the toxicity of C4F7N on mice and rats is also evaluated. We find that the LC50of C4F7N for male and female mice is 1175 ppm (4 h), 1380 ppm (4 h) and female ones are more tolerant to C4F7N. Mice that exposed to 1000 ppm C4F7N for 4 h could survive and return to their normal state after the 14-day observation period without irreversible damage. The toxic effect duration of C4F7N on rats is longer than that of mice. Relevant results revealed the acute inhalation toxicity of C4F7N systematically and provided fundamental reference for inhalation safety protection and engineering application.