Leveraging the United States Epicenter to Provide Insights on COVID-19 in Patients With Systemic Lupus Erythematosus.
Leveraging the United States Epicenter to Provide Insights on COVID-19 in Patients With Systemic Lupus Erythematosus.
复制标题
DOI：
10.1002/art.41450
复制
发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
NYU WARCOV Investigators
中科院分区：
文献类型：
--
作者：
Fernandez-Ruiz R;Masson M;Kim MY;Myers B;Haberman RH;Castillo R;Scher JU;Guttmann A;Carlucci PM;Deonaraine KK;Golpanian M;Robins K;Chang M;Belmont HM;Buyon JP;Blazer AD;Saxena A;Izmirly PM;NYU WARCOV Investigators
旨在描述受 COVID-19 影响的系统性红斑狼疮 (SLE) 患者的特征，并分析合并症和药物与感染结果的关联。 SLE 和 RT-PCR 确诊的 COVID-19 患者是通过纽约大学狼疮队列、两个医院系统的查询以及风湿病专家的转诊来确定的。通过基于网络的调查问卷和医疗记录审查前瞻性地收集数据。获取所有 COVID-19 患者的基线特征，以分析住院的危险因素。数据还收集自无症状患者和具有类似 COVID-19 症状且检测结果呈阴性或未进行检测的患者。统计分析仅限于确诊的 COVID-19 阳性患者。总共纳入了 226 名 SLE 患者：41 名确诊为 COVID-19 的患者； 19 名患者的 COVID-19 检测呈阴性； 42 名出现类似 COVID-19 症状但未接受检测的患者；以及 124 名未经检测仍无症状的患者。在患有 COVID-19 的 SLE 患者中，24 名 (59%) 需要住院治疗，4 名需要重症监护病房级别的护理，4 名死亡。住院患者往往年龄较大、非白人、西班牙裔、体重指数较高、有肾炎病史和至少一种合并症。一项探索性（由于样本量有限）逻辑回归分析将种族、至少一种合并症的存在和体重指数确定为住院治疗的独立预测因素。一般来说，预测 SLE 患者住院的变量与一般人群中确定的变量相似。需要进一步研究来了解导致 SLE 患者 COVID-19 预后不良的其他危险因素。
To characterize patients with Systemic Lupus Erythematosus (SLE) affected by COVID-19 and to analyze associations of comorbidities and medications on infection outcomes. Patients with SLE and RT-PCR-confirmed COVID-19 were identified through an established New York University lupus cohort, query of two hospital systems, and referrals from rheumatologists. Data were prospectively collected via a web-based questionnaire and review of medical records. Baseline characteristics were obtained for all patients with COVID-19 to analyze risk factors for hospitalization. Data were also collected from asymptomatic patients and those with COVID-19-like symptoms who tested negative or were not tested. Statistical analyses were limited to confirmed COVID-19-positive patients. A total of 226 SLE patients were included: 41 patients with confirmed COVID-19; 19 patients who tested negative for COVID-19; 42 patients with COVID-19-like symptoms who did not get tested; and 124 patients who remained asymptomatic without testing. Of those SLE patients with COVID-19, 24 (59%) required hospitalization, four required intensive care unit-level of care, and four died. Hospitalized patients tended to be older, non-white, Hispanic, have higher BMI, history of nephritis, and at least one comorbidity. An exploratory (due to limited sample size) logistic regression analysis identified race, presence of at least one comorbidity, and BMI as independent predictors of hospitalization. In general, the variables predictive of hospitalization in our SLE patients were similar to those identified in the general population. Further studies are needed to understand additional risk factors for poor COVID-19 outcomes in patients with SLE.
登录
查看更多内容
影响因子：
25.4
作者：
Guaraldi, Giovanni;Meschiari, Marianna;Mussini, Cristina
通讯作者：
Mussini, Cristina
影响因子：
158.5
作者：
Boulware, David R.;Pullen, Matthew F.;Hullsiek, Kathy H.
通讯作者：
Hullsiek, Kathy H.
影响因子：
158.5
作者：
Grein, J.;Ohmagari, N.;Flanigan, T.
通讯作者：
Flanigan, T.
影响因子：
15.1
作者：
Kewan, Tariq;Covut, Fahrettin;Akbik, Bassel
通讯作者：
Akbik, Bassel
影响因子：
13.3
作者：
Aringer, Martin;Costenbader, Karen;Johnson, Sindhu R.
通讯作者：
Johnson, Sindhu R.