Stimulus functions of nicotine.
Stimulus functions of nicotine.
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DOI：
10.1016/bs.apha.2021.11.001
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
LeSage, Mark G
中科院分区：
文献类型：
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作者：
LeSage, Mark G
行为药理学对烟草和其他药物使用研究中使用的概念和方法做出了重要贡献，并且在很大程度上导致了现在普遍接受的概念，即尼古丁是烟草中产生和维持烟草使用的主要成分。行为药理学对药物使用科学最重要的贡献之一是药物可以作为环境刺激物，以与其他刺激物（例如视觉，味觉，嗅觉）相同的方式控制行为。本章的目的是提供一个概述的研究，说明尼古丁的应答和操作性刺激功能，使用当代分类的刺激功能作为一个一般框架。每个功能正式定义和尼古丁的行为药理学研究的例子。还讨论了调节每个功能的一些因素。尼古丁的刺激功能在烟草使用的操作和响应理论的作用进行了检查，并提出了一些建议，为今后的研究。本章说明了刺激功能的分类如何指导烟草使用的概念，并相应地指导研究和理论。
Behavioral pharmacology has made vital contributions to the concepts and methods used in tobacco and other drug use research, and is largely responsible for the now generally accepted notion that nicotine is the primary component in tobacco that engenders and maintains tobacco use. One of the most important contributions of behavioral pharmacology to the science of drug use is the notion that drugs can act as environmental stimuli that control behavior in many of the same ways as other stimuli (e.g. visual, gustatory, olfactory). The purpose of this chapter is to provide an overview of research that illustrates the respondent and operant stimulus functions of nicotine, using a contemporary taxonomy of stimulus functions as a general framework. Each function is formally defined and examples from research on the behavioral pharmacology of nicotine are presented. Some of the factors that modulate each function are also discussed. The role of nicotine’s stimulus functions in operant and respondent theories of tobacco use is examined and some suggestions for future research are presented. The chapter illustrates how a taxonomy of stimulus functions can guide conceptions of tobacco use and direct research and theory accordingly.