Plasmonic Nanopowders for Photothermal Therapy of Tumors
Plasmonic Nanopowders for Photothermal Therapy of Tumors
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DOI：
10.1021/la300022k
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发表时间：
2012-06-19
期刊：
影响因子：
3.9
通讯作者：
Khlebtsov, Nikolai G.
中科院分区：
文献类型：
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作者：
Khlebtsov, Boris N.;Panfilova, Elizaveta V.;Khlebtsov, Nikolai G.
我们描述了一种通过使用湿化学纳米颗粒合成、PEG-SH 功能化和标准冷冻干燥技术来制造等离子体纳米粉末（干燥金纳米颗粒）的新策略。我们的策略通过成功制造不同的等离子体纳米粉末来说明，包括金纳米棒、金银纳米笼和金纳米球。重要的是，干燥的纳米颗粒可以在通常条件下长期保存，然后可以轻松地以所需浓度溶解在水中，而无需进行超声处理或加热等硬操作。再分散的样品保持了母体胶体的等离子体特性并且不形成聚集体。这些特性使得聚乙二醇化冻干金纳米粒子成为临床环境中等离子体光热疗法的有吸引力的候选者。在这项工作中，将再分散的金纳米棒以 2 和 8 mg (Au)/kg（动物）的剂量静脉注射给患有艾利希癌肿瘤的小鼠。通过原子吸收光谱测量颗粒生物分布，并研究激光近红外照射下的肿瘤热疗效应。仅在较高剂量的纳米棒下才观察到显着的肿瘤损伤。
We describe a novel strategy for the fabrication of plasmonic nanopowders (dried gold nanoparticles) by using wet chemical nanoparticle synthesis, PEG-SH functionalization, and a standard freeze-drying technique. Our strategy is illustrated by successful fabrication of different plasmonic nanopowders, including gold nanorods, gold silver nanocages, and gold nanospheres. Importantly, the dried nanoparticles can be stored for a long time under usual conditions and then can easily be dissolved in water at a desired concentration without such hard manipulations as sonication or heating. Redispersed samples maintain the plasmonic properties of parent colloids and do not form aggregates. These properties make pegylated freeze-dried gold nanoparticles attractive candidates for plasmonic photothermal therapy in clinical settings. In this work, redispersed gold nanorods were intravenously administered to mice bearing Ehrlich carcinoma tumors at doses of 2 and 8 mg (Au)/kg (animal). Particle biodistribution was measured by atomic absorption spectroscopy, and tumor hyperthermia effects were studied under laser NIR irradiation. Significant tumor damage was observed only at the higher dose of the nanorods.