The cerebellum: A neuronal learning machine?
The cerebellum: A neuronal learning machine?
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DOI：
10.1126/science.272.5265.1126
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发表时间：
1996-05-24
期刊：
影响因子：
56.9
通讯作者：
Mauk, MD
中科院分区：
文献类型：
--
作者：
Raymond, JL;Lisberger, SG;Mauk, MD
通过比较两种看似完全不同的行为，我们发现小脑在运动学习中的作用是惊人一致的。有关眼睑反应的经典条件反射和前庭眼反射中运动学习的行为和生理数据表明：（1）可塑性分布在小脑皮质和小脑深核之间;（ii）小脑皮质在学习运动的时间方面起着特殊的作用;（iii）小脑皮质在深层核团中指导学习，这可能使学习从皮质转移到深层核团。由于这两个系统的数据中的许多相似之处代表了小脑组织的一般特征，这两个系统中的小脑学习机制可能代表了适用于许多运动系统的原则。
Comparison of two seemingly quite different behaviors yields a surprisingly consistent picture of the role of the cerebellum in motor learning, Behavioral and physiological data about classical conditioning of the eyelid response and motor learning in the vestibuloocular reflex suggest that (i) plasticity is distributed between the cerebellar cortex and the deep cerebellar nuclei; (ii) the cerebellar cortex plays a special role in learning the timing of movement; and (iii) the cerebellar cortex guides learning in the deep nuclei, which may allow learning to be transferred from the cortex to the deep nuclei. Because many of the similarities in the data from the two systems typify general features of cerebellar organization, the cerebellar mechanisms of learning in these two systems may represent principles that apply to many motor systems.