High-resolution mechanical mapping of the adhesive?dentin interface: The effect of co-monomers in 10-methacryloyloxydecyl dihydrogen phosphate
High-resolution mechanical mapping of the adhesive?dentin interface: The effect of co-monomers in 10-methacryloyloxydecyl dihydrogen phosphate
复制标题
粘合剂-牙本质界面的高分辨率机械测绘：10-甲基丙烯酰氧基癸基磷酸二氢盐中共聚单体的作用
DOI：
10.1016/j.jmbbm.2021.104389
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发表时间：
2021
影响因子：
3.9
通讯作者：
Miyazaki Takashi
中科院分区：
文献类型：
--
作者：
Takahashi Shinpei;Zhou Jun;Wurihan;Shimomura Naofumi;Kataoka Yu;Watanabe Chie;Shibata Yo;Funatsu Takahiro;Gao Ping;Miyazaki Takashi
10-甲基丙烯酰氧基癸基磷酸二氢盐（MDP）在粘合剂-牙本质界面的存在下，使离子结合到钙盐，这导致在亚微米级的树脂-牙本质相互扩散区内的刚性纳米分层。MDP已经与另外的共聚单体如甲基丙烯酸羟乙酯（HEMA）和/或4-甲基丙烯酰氧基乙基-偏苯三酸（4-MET）一起使用，主要是为了增强化学键合性质。然而，共聚单体的使用可能损害粘合剂-牙本质界面的刚性。在这项研究中，我们使用高分辨率的机械映射整个接口，以辨别在纳米级的每个目标区域的原位机械性能。通过模量映射的可视化表明，HEMA增加了MDP进入牙本质结构的扩散性质。然而，由储能模量表示的粘合剂-牙本质界面的刚度在含有HEMA的MDP中明显低于含有4-MET的MDP。动态压痕试验表明，在HEMA的存在下，粘结层更易变形。此外，粘合层中MDP的存在也可能增加可变形性，因为聚合线性允许大程度的粘弹性。这些因素也降低了粘合剂-牙本质界面的刚性。在本研究的限制范围内，我们的研究结果表明，在基于MDP的牙科粘合剂中，4-MET是比HEMA更好的共聚单体。模量映射和纳米压痕被引入作为新的测试粘合剂-牙本质界面，以解决有关牙科粘合剂的有效性的查询。
The presence of 10-methacryloyloxydecyl dihydrogen phosphate (MDP) at the adhesive–dentin interface enables ionic binding to calcium salts, which results in rigid nano-layering within the submicron scale resin–dentin interdiffusion zone. MDP has been used with additional co-monomers, such as hydroxyethyl methacrylate (HEMA) and/or 4-methacryloyloxyethyl-trimellitic acid (4-MET), mainly to enhance the chemical bonding properties. However, the use of co-monomers may compromise the rigidity of the adhesive–dentin interface. In this study, we use high-resolution mechanical mapping across the interface to discern the in situ mechanical properties of each target region at the nanoscale. Visualization by modulus mapping demonstrated that HEMA increases the diffusion properties of MDP into dentin structures. However, the rigidity of the adhesive–dentin interface indicated by the storage modulus was markedly lower in MDP containing HEMA than in MDP containing 4-MET. Dynamic indentation testing revealed that the bonding layer was more deformable in the presence of HEMA. Moreover, the presence of MDP in the bonding layer might also increase the deformability because the polymerization linearity allows a large degree of viscoelasticity. These factors also diminish the rigidity of the adhesive–dentin interface. Within the limitations of this study, our findings demonstrated that 4-MET is a better co-monomer than HEMA in MDP-based dental adhesives. Modulus mapping and nanoindentation are introduced as new tests for the adhesive–dentin interface to address queries about the effectiveness of dental adhesives.