Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers.
Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers.
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DOI：
10.1016/j.ccell.2018.08.019
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发表时间：
2018-10-08
期刊：
影响因子：
50.3
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Yuan J;Hu Z;Mahal BA;Zhao SD;Kensler KH;Pi J;Hu X;Zhang Y;Wang Y;Jiang J;Li C;Zhong X;Montone KT;Guan G;Tanyi JL;Fan Y;Xu X;Morgan MA;Long M;Zhang Y;Zhang R;Sood AK;Rebbeck TR;Dang CV;Zhang L
癌症治疗的差异一直是一个长期的挑战。我们估计了癌症基因组图谱患者的遗传祖先，并对遗传祖先对基因组改变的影响进行了泛癌症分析。与欧洲裔美国人相比，患有乳腺癌、头颈癌和子宫内膜癌的非洲裔美国人（AA）表现出更高水平的染色体不稳定性，而在患有肾癌的AA中观察到更低水平的染色体不稳定性。TP53突变和CCNE1扩增的频率在显示较高水平的染色体不稳定性的癌症类型中的AA中增加。我们观察到在所有癌症中，AA患者中影响PI3K通路基因的基因组改变频率较低。我们的结果提供了对基因组对癌症差异的贡献的见解。通过分析TCGA队列，Yuan等人表明，非洲裔美国人（AA）的乳腺癌、头颈癌和子宫内膜癌的染色体不稳定性水平高于欧洲裔美国人，而AA患者中PI3K通路的遗传变异频率在癌症中较低。
Disparities in cancer care have been a long-standing challenge. We estimated the genetic ancestry of The Cancer Genome Atlas patients, and performed a pan-cancer analysis on the influence of genetic ancestry on genomic alterations. Compared with European Americans, African Americans (AA) with breast, head and neck, and endometrial cancers exhibit a higher level of chromosomal instability, while a lower level of chromosomal instability was observed in AAs with kidney cancers. The frequencies of TP53 mutations and amplification of CCNE1 were increased in AAs in the cancer types showing higher levels of chromosomal instability. We observed lower frequencies of genomic alterations affecting genes in the PI3K pathway in AA patients across cancers. Our result provides insight into genomic contribution to cancer disparities. By analyzing TCGA cohorts, Yuan et al. show that breast, head and neck, and endometrial cancers of African Americans (AA) have higher levels of chromosomal instability than those of European Americans whereas the frequency of genetic alternations in the PI3K pathway in AA patients is lower across cancers.
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影响因子：
64.8
作者：
Burrell RA;McClelland SE;Endesfelder D;Groth P;Weller MC;Shaikh N;Domingo E;Kanu N;Dewhurst SM;Gronroos E;Chew SK;Rowan AJ;Schenk A;Sheffer M;Howell M;Kschischo M;Behrens A;Helleday T;Bartek J;Tomlinson IP;Swanton C
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影响因子：
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作者：
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通讯作者：
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影响因子：
9.8
作者：
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通讯作者：
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作者：
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