Hematologic differences between African-Americans and whites:: the roles of iron deficiency and α-thalassemia on hemoglobin levels and mean corpuscular volume
Hematologic differences between African-Americans and whites:: the roles of iron deficiency and α-thalassemia on hemoglobin levels and mean corpuscular volume
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DOI：
10.1182/blood-2005-02-0713
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发表时间：
2005-07-15
期刊：
影响因子：
20.3
通讯作者：
West, C
中科院分区：
文献类型：
--
作者：
Beutler, E;West, C
一些实验室测量的平均结果，包括血红蛋白，平均红细胞体积（MCV），血清转铁蛋白饱和度（TS），血清铁蛋白，和白色血细胞计数的非洲裔美国人不同于白人。分析了来自1491名非洲裔美国人和31005名白色受试者（男性和女性大致相等）的分析样本和实验室数据。非裔美国人的红细胞压积、血红蛋白、MCV、TS和白色血细胞计数低于白人;血清铁蛋白水平高于白人。当排除缺铁患者后，女性的红细胞压积、血红蛋白和MCV的差异略小，-3.7-β-地中海贫血缺失占非裔美国人和白人血红蛋白水平差异的三分之一，镰刀型特征和肌酐水平升高都没有影响。在所有受试者中，19.8%的非洲裔美国妇女被归类为“贫血”，而白人的这一比例为5.3%。在男子中，这两个数字分别为17.7%和7.6%。如果没有缺铁或地中海贫血的受试者，差异分别缩小到6.1%和2.77%以及4.29%和3.6%。医生需要考虑到血红蛋白、红细胞压积、MCV和TS以及白色血细胞计数的相同参考标准并不适用于所有种族。
The average results of some laboratory measurements, including the hemoglobin, mean corpuscular volume (MCV), serum transferrin saturation (TS), serum ferritin, and white blood cell count of African-Americans differ from those of whites. Anonymized samples and laboratory data from 1491 African-American and 31 005 white subjects, approximately equally divided between men and women, were analyzed. The hematocrit, hemoglobin, MCV, TS, and white blood cell counts of African-Americans were lower than those of whites; serum ferritin levels were higher. When iron-deficient patients were eliminated from consideration the differences in hematocrit, hemoglobin, and MCV among women were slightly less. The -3.7-kilobase alpha-thalassemia deletion accounted for about one third of the difference in the hemoglobin levels of African-Americans and whites and neither sickle trait nor elevated creatinine levels had an effect. Among all subjects, 19.8% of African-American women would have been classified as "anemic" compared with 5.3% of whites. Among men, the figures were 17.7% and 7.6%. Without iron-deficient or thalassemic subjects, the difference had narrowed to 6.1% and 2.77% and to 4.29% and 3.6%, respectively. Physicians need to take into account that the same reference standards for hemoglobin, hematocrit, MCV, and TS and the white blood cell count do not apply to all ethnic groups.