Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behćet's disease.
Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behćet's disease.
复制标题
HLA-B51、-B52 和 -B78 分子的肽基序以及对白塞氏病的影响。
DOI：
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发表时间：
1995
影响因子：
4.4
通讯作者：
H. Rammensee
中科院分区：
文献类型：
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作者：
K. Falk;O. Rötzschke;Masafumi Takiguchi;V. Gnau;S. Stevanović;Günther Jung;H. Rammensee
本文报道了B*5101、B*5102、B*5103、B*5201和B*7801这五个人类白细胞抗原-B分子的多肽基序。通过对C1R细胞中表达的各个分子在转染后洗脱出来的天然配体进行池测序，获得基序。一些可以测序的单个配体证实了这些基序。这5个人类白细胞抗原-B分子都属于人类白细胞抗原-B5、B35-交叉反应基团，从相似的序列可以看出它们有密切的亲缘关系。B51和B52与Bw4相关，而B78与Bw6相关。这里研究的人类白细胞抗原-B分子之一，人类白细胞抗原-B*5101，与白塞病有关，白塞病是一种影响多种器官的多系统炎症性疾病。这种疾病在日本人中尤其常见。B*5101的多肽基序与其他四个密切相关但与疾病无关的分子的基序之间的细微差异可能有助于揭示Behçet病与人类白细胞抗原相关的本质。
Here we report peptide motifs of five HLA-B molecules, B*5101, B*5102, B*5103 B*5201 and B*7801. Motifs were obtained by pool sequencing of natural ligands eluted from the respective molecules expressed in C1R cells upon transfection. A number of individual ligands that could be sequenced confirmed the motifs. All five HLA-B molecules belong to the HLA-B5, B35-cross-reactive group and are closely related as indicated by similar sequences. B51 and B52 are associated with Bw4, whereas B78 is associated with Bw6. One of the HLA-B molecules investigated here, HLA-B*5101, is associated with Behçet's disease, a multisystemic inflammatory disease affecting various organs. This disease is especially frequent among the Japanese population. The subtle differences between the peptide motifs of B*5101 as compared with the motifs of the four other closely related but not disease-associated molecules could shed light on the nature of the HLA-association of Behçet's disease.