Stimulation in vivo of the secretion of prolactin and growth hormone by beta-endorphin.
Stimulation in vivo of the secretion of prolactin and growth hormone by beta-endorphin.
复制标题
β-内啡肽刺激体内催乳素和生长激素的分泌。
作者：
C. Rivier;W. Vale;N. Ling;Marvin R. Brown;R. Guillemin
硫酸吗啡 (MS) 和阿片肽 β-内啡肽 β-LPH-(61-91) 在静脉内或脑池内注射时，会刺激类固醇引发和未治疗的雄性大鼠释放催乳素和生长激素。按摩尔计算，β-内啡肽的效力至少是 MS 的 20 倍，而 Met5-脑啡肽 (β-LPH-(61-65)) 和 α-内啡肽 (β-LPH-(61-76)) 在注射剂量（300 杯）下缺乏活性。 β-内啡肽对催乳素分泌的体内刺激作用可被阿片拮抗剂纳洛酮逆转。 MS 和 β-内啡肽在体外对培养的大鼠垂体细胞的催乳素和生长激素分泌没有影响，这表明它们具有中枢神经系统作用位点。
Morphine sulfate (MS) and the opioid peptide beta-endorphin beta-LPH-(61-91) stimulate prolactin and growth hormone release in steroid-primed and non-treated male rats when injected intravenously or intracisternally. On a molar basis beta-endorphin is at least 20 times more potent than MS, whereas Met5-enkephalin (beta-LPH-(61-65)) and alpha-endorphin (beta-LPH-(61-76)) are devoid of activity at the dose injected (300 mug). The in vivo stimulatory effects of beta-endorphin on prolactin secretion are reversed by the opiate antagonist naloxone. The absence of in vitro effect of MS and beta-endorphin on prolactin and growth hormone secretion by cultured rat pituitary cells suggest that they have a central nervous system site of action.