The TOR Pathway Couples Nutrition and Developmental Timing in Drosophila
The TOR Pathway Couples Nutrition and Developmental Timing in Drosophila
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DOI：
10.1016/j.devcel.2008.08.003
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发表时间：
2008-10-14
影响因子：
11.8
通讯作者：
Leopold, Pierre
中科院分区：
文献类型：
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作者：
Layalle, Sophie;Arquier, Nathalie;Leopold, Pierre
在许多后生动物中，最终成虫的大小取决于生长速度和生长期的长短，这两个参数受营养因素的影响。我们证明，在果蝇中，营养通过作用于分泌蜕皮激素的前胸腺（PG）来改变发育时间。当营养反应通路的核心成分雷帕霉素靶蛋白（Target of Rapamycin， TOR）的活性在PG中降低时，标志着幼虫发育结束的蜕皮激素峰值就消失了。这延长了生长的时间，增加了动物的体型。相反，仅在PG细胞中激活TOR可逆转由营养限制引起的发育迟缓。最后，营养作用于PG在一个有限的时间窗口，接近幼虫发育的结束，与化蛹的承诺一致。总之，PG使用TOR信号将营养输入与蜕皮激素的产生和发育时间结合起来。
In many metazoans, final adult size depends on the growth rate and the duration of the growth period, two parameters influenced by nutritional cues. We demonstrate that, in Drosophila, nutrition modifies the timing of development by acting on the prothoracic gland (PG), which secretes the molting hormone ecdysone. When activity of the Target of Rapamycin (TOR), a core component of the nutrient-responsive pathway, is reduced in the PG, the ecdysone peak that marks the end of larval development is abrogated. This extends the duration of growth and increases animal size. Conversely, the developmental delay caused by nutritional restriction is reversed by activating TOR solely in PG cells. Finally, nutrition acts on the PG during a restricted time window near the end of larval development that coincides with the commitment to pupariation. In conclusion, the PG uses TOR signaling to couple nutritional input with ecdysone production and developmental timing.