High production of RANTES and MIP-1α in the tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM)
High production of RANTES and MIP-1α in the tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM)
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DOI：
10.1016/j.jneuroim.2007.05.015
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发表时间：
2007-08-01
影响因子：
3.3
通讯作者：
Casseb, Jorge
中科院分区：
文献类型：
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作者：
Montanheiro, Patricia;Posada Vergara, Maria Paulina;Casseb, Jorge
人类T淋巴细胞嗜淋性病毒I型(HTLV-1)感染与进行性神经系统疾病和热带痉挛截瘫/HTLV-I型相关性脊髓病(TSP/HAM)有关。TSP/HAM的发病机制被认为是免疫介导的，涉及细胞毒性T细胞(CTL)对多种病毒蛋白的反应，尤其是调节蛋白TAX。T CD8+细胞产生在抗病毒反应中起重要作用的β-趋化因子。在本研究中，我们分析了逆转录病毒感染者CC趋化因子(RANTES、MIP-1β和MIP-Iα)的产生。研究对象为191名受试者：52名健康对照、72名无症状HTLV-1感染携带者和67名TSP/HAM患者。外周血单核细胞在PHA存在或不存在的情况下保持，上清液用EIA进行检测。MIP-1β浓度在三组间无显著差异，但RANTES和MIP-1α浓度在三组比较时有显著差异。在TSP/HAM患者中，趋化因子的产生增加可能导致促炎因子的募集，从而导致膜的髓鞘损伤。(C)2007爱思唯尔B.V保留所有权利。
Human T cell lymphotropic, virus type I (HTLV-1) infection is associated with progressive neurological disorders and tropical spastic paraparesis/HTLV- I -associated myelopathy (TSP/HAM). The pathogenesis of TSP/HAM is considered as imirume mediated, involving cytotoxic T cell (CTL) responses to a number of viral proteins and notably the regulation protein Tax. T CD8+ cells produce beta-chemokines, which are important in the anti-viral response. In the present study, we have analyzed the CC chemokines (RANTES, MIP-1 beta and MIP- I alpha) production in retrovirus-infected subjects. A total of 191 subjects were studied: 52 healthy controls, 72 asymptornatic HTLV-1-infected carriers and 67 TSP/ HAM patients. Peripheral blood mononuclear cells were maintained in the presence or absence of PHA, and supernatant fluids were assayed using EIA. MIP-1 beta concentration was not significantly different across groups, but RANTES and MIP-1 alpha concentrations showed significant differences when the three groups were compared. In TSP/HAM patients, the increase in the production of chemokines may lead to a recruitment of proinflammatory factors, contributing to the membrane's myelin damage. (c) 2007 Elsevier B.V All rights reserved.