Fluctuations of fitness distributions and the rate of Muller's ratchet.
Fluctuations of fitness distributions and the rate of Muller's ratchet.
复制标题
健身分布的波动和穆勒棘轮的速度。
DOI：
10.1534/genetics.112.141325
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发表时间：
2012-08
期刊：
影响因子：
3.3
通讯作者：
Shraiman BI
中科院分区：
文献类型：
--
作者：
Neher RA;Shraiman BI
The accumulation of deleterious mutations is driven by rare fluctuations that lead to the loss of all mutation free individuals, a process known as Muller’s ratchet. Even though Muller’s ratchet is a paradigmatic process in population genetics, a quantitative understanding of its rate is still lacking. The difficulty lies in the nontrivial nature of fluctuations in the fitness distribution, which control the rate of extinction of the fittest genotype. We address this problem using the simple but classic model of mutation selection balance with deleterious mutations all having the same effect on fitness. We show analytically how fluctuations among the fittest individuals propagate to individuals of lower fitness and have dramatically amplified effects on the bulk of the population at a later time. If a reduction in the size of the fittest class reduces the mean fitness only after a delay, selection opposing this reduction is also delayed. This delayed restoring force speeds up Muller’s ratchet. We show how the delayed response can be accounted for using a path-integral formulation of the stochastic dynamics and provide an expression for the rate of the ratchet that is accurate across a broad range of parameters.
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影响因子：
2.1
作者：
Oliphant, Travis E.
通讯作者：
Oliphant, Travis E.
DOI：
10.1073/pnas.242719299
发表时间：
2003-01-21
影响因子：
11.1
作者：
Rouzine, IM;Wakeley, J;Coffin, JM
通讯作者：
Coffin, JM
影响因子：
3.3
作者：
Jain, Kavita
通讯作者：
Jain, Kavita
影响因子：
3.3
作者：
Neher, R. A.;Shraiman, B. I.
通讯作者：
Shraiman, B. I.
影响因子：
1.4
作者：
HAIGH, J
通讯作者：
HAIGH, J