MAMMARY TUMORS IN AGENT‐FREE MICE
MAMMARY TUMORS IN AGENT‐FREE MICE
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无药物小鼠的乳腺肿瘤
DOI：
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发表时间：
1958
影响因子：
5.2
通讯作者：
W. E. Heston
中科院分区：
文献类型：
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作者：
W. E. Heston
本文讨论了通过寄养喂养剥夺乳腺肿瘤剂的 4 个 C3H 品系小鼠亚系的繁殖雌性中发生的肿瘤，并指定为 C3Hf C3Hff C3Hf/2 和 C3Hf/An 亚系。 911 名 C3Hf 女性中有 22% 在平均 20 个月大时患上乳腺肿瘤。 118 名 C3Hff 女性中，平均年龄 19 个月时，有 29% 发生肿瘤；72 名 C3Hf/2 女性中，平均年龄 20 个月时，有 51% 发生肿瘤；96 名 C3Hf/An 女性中，平均年龄 20 个月时，有 27% 发生肿瘤。相比之下，97% 的 C3H 繁殖雌性在平均 7.8 个月大时出现乳腺肿瘤。在 4 个无药物亚系中患有肿瘤的雌性中，没有观察到高肿瘤系分离的证据。母亲未患乳腺肿瘤而死亡的女儿的乳腺肿瘤发病率与母亲后来患乳腺肿瘤的女儿的乳腺肿瘤发病率一样高，甚至更高。 C3Hf 雌性产仔数与乳腺肿瘤的发生率呈正相关；未婚雌性的发病率为 2%，每胎 7 胎的雌性的发病率为 44%。这些亚系中乳腺肿瘤的发生归因于高遗传易感性、繁殖产生的激素刺激和雌性高龄。在这些未使用药物的女性中发生的 311 例乳腺肿瘤中，251 例为 A 型或 B 型腺癌，1 例为 C 型腺癌，53 例为腺棘皮瘤，6 例为癌肉瘤。
This paper discusses tumors occurring in breeding females of 4 substrains of strain C3H mice deprived of the mammary tumor agent by foster nursing and designated as substrains C3Hf C3Hff C3Hf/2 and C3Hf/An. 22% of the 911 C3Hf females developed mammary gland tumors at an average age of 20 months. The tumors also occurred in 29% of the 118 C3Hff females at an average age of 19 months in 51% of the 72 C3Hf/2 females at an average age of 20 months and in 27% of the 96 C3Hf/An females at an average age of 20 months. In comparison 97% of the C3H breeding females developed mammary tumors at an average age of 7.8 months. No evidence of segregation of high-tumor lines was observed in the females with tumors in the 4 agent-free substrains. The incidence of mammary tumors was as high as or higher in daughters of mothers that died without mammary tumors than in those with mothers that later developed mammary tumors. A positive correlation was noted between the number of litters the C3Hf females produced and the incidence of mammary tumors; the incidences ranged from 2% in virgin females to 44% in females that had 7 litters each. The development of mammary tumors in these substrains is attributed to high genetic susceptivility the hormonal stimulation from breeding and the females advanced ages. Of the 311 mammary tumors occurring in these agent-free females 251 were adenocarcinomas of either type A or type B 1 was adenocarcinoma type C 53 were adenoacanthomas and 6 were carcinosarcomas.