Clinical and Dosimetric Factors Predicting Grade ≥2 Radiation Pneumonitis After Postoperative Radiotherapy for Patients With Non-Small Cell Lung Carcinoma
Clinical and Dosimetric Factors Predicting Grade ≥2 Radiation Pneumonitis After Postoperative Radiotherapy for Patients With Non-Small Cell Lung Carcinoma
复制标题
非小细胞肺癌患者术后放疗后预测≥2级放射性肺炎的临床和剂量学因素
DOI：
10.1016/j.ijrobp.2018.04.012
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发表时间：
2018-07-15
影响因子：
7
通讯作者：
Liao, Zhongxing
中科院分区：
文献类型：
--
作者：
Boonyawan, Keeratikarn;Gomez, Daniel R.;Liao, Zhongxing
Purpose: To identify clinical and dosimetric factors that would predict grade >= 2 radiation pneumonitis (RP) for patients undergoing postoperative radiation therapy (PORT) for non-small cell lung cancer (NSCLC); and to use the factors identified to generate a predictive model to quantify risk of RP in such patients.Methods and Materials: We retrospectively reviewed radiation therapy, radiographic, and clinical data from 199 patients who had received PORT, with or without chemotherapy, for NSCLC. Potential associations between dosimetric and clinical factors and RP were evaluated in univariate and multivariate Cox regression hazard models and competing risk analysis. Kaplan-Meier analysis was used to estimate overall survival and the cumulative incidence of RP, and receiver operating characteristic curve analysis to identify cutpoints for variables found to influence RP risk. The endpoint was grade >= 2 RP (symptomatic, requiring steroids or limiting instrumental activities of daily living).Results: Thirty-seven patients (19%) developed grade >= 2 RP. Patient-related factors, type of surgery or chemotherapy, and radiation therapy-related factors were not associated with grade >= 2 RP; only lung V10 > 30% and lung V20 > 20% predicted grade >= 2 RP. Risk groupings were as follows: high risk, V10 > 30% and V20 > 20% (24 of 72 patients, 33%); intermediate risk, V10 > 30% and V20
