Altered expression of CD44 in human prostate cancer during progression.
Altered expression of CD44 in human prostate cancer during progression.
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DOI：
10.1093/ajcp/106.5.647
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发表时间：
1996-11
影响因子：
3.5
通讯作者：
M. Nagabhushan;T. Pretlow;Y. Guo;S. Amini;T. P. Pretlow;M. Sy
中科院分区：
文献类型：
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作者：
M. Nagabhushan;T. Pretlow;Y. Guo;S. Amini;T. P. Pretlow;M. Sy
在石蜡包埋组织中，非常需要能够区分缓慢进展和快速进展前列腺癌的标志物。CD44是一种粘附分子，对预测其他一些癌症的预后很有用，但尚未在前列腺癌中发现。用单克隆抗体GKW检测CD44的表达。74例前列腺癌50例，经福尔马林固定、石蜡包埋的全前列腺组织切片显示A3；(2)淋巴结转移14例。60%的原发性前列腺癌中度至强烈表达CD44。没有CD44中度至强烈表达的转移灶；只有14%的转移瘤表达低水平的免疫组织化学检测到的CD44。原发性前列腺癌和转移性前列腺癌的CD44表达存在差异（P < 0.0006），组织学分化（Gleason分级）与CD44表达呈负相关（P < 0.05）。CD44在原发性和转移性前列腺癌中的差异表达程度表明，应该在一项大型前瞻性研究中将其作为预后指标进行研究。
There is a great need for markers that distinguish slowly progressive from rapidly progressive prostate cancers in paraffin-embedded tissues. CD44, an adhesion molecule that has been useful for the prediction of prognosis in some other cancers, has not been described in prostate cancer. The expression of CD44 was investigated with the monoclonal antibody GKW.A3 in prostate cancer in formalin-fixed, paraffin-embedded tissue sections of (1) whole prostates from 50 patients with 74 prostate cancers; and (2) lymph node metastases from 14 patients. Sixty percent of primary prostate cancers expressed CD44 moderately to strongly. No metastases expressed CD44 moderately to strongly; only 14% of metastases expressed even low levels of immunohistochemically detectable CD44. There is a difference between primary and metastatic prostate cancer (P <.0006) in the expression of CD44 and an inverse correlation (P <.05) between histological differentiation (Gleason grade) and the expression of CD44. The magnitude of the differential expression of CD44 in primary and metastatic prostate cancers suggests it should be investigated as an indicator of prognosis in a large prospective study.