Reliability of studies of iodine intake and recommendations for number of samples in groups and in individuals
Reliability of studies of iodine intake and recommendations for number of samples in groups and in individuals
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DOI：
10.1017/s0007114507842292
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发表时间：
2008-04-01
影响因子：
3.6
通讯作者：
Laurberg, Peter
中科院分区：
文献类型：
--
作者：
Andersen, Stig;Karmisholt, Jesper;Laurberg, Peter
在横断面研究中确定人群中的碘摄入水平。尿碘差异很大，碘营养研究的可靠性和所需样本数量尚不确定。我们进行了一项纵向研究的16名健康男子生活在一个地区的轻度至中度碘缺乏症。在13个月内每月收集一次现场尿样，测量碘和肌酐浓度。根据这些数据，我们计算了确定粗尿碘和根据年龄和性别特异性肌酐排泄量估计的24小时碘排泄量的碘排泄水平所需的尿样数量。我们发现，平均尿碘排泄量为30至87微克/升（31至91微克/24小时）。样品碘含量从10到260微克/升（20到161微克/24小时）不等。粗尿碘的变化大于估计的24小时碘排泄量（群体标准差32 v.26;个体标准差29 v.21; Bartlett检验，P
The iodine intake level in a population is determined in cross-sectional studies. Urinary iodine varies considerably and the reliability of studies of iodine nutrition and the number of samples needed is unsettled. We performed a longitudinal study of sixteen healthy men living in an area of mild to moderate iodine deficiency. Iodine and creatinine concentrations were measured in spot urine samples collected monthly for 13 months. From these data we calculated the number of urine samples needed to determine the iodine excretion level for crude urinary iodine and for 24 h iodine excretion estimated from age- and gender-specific creatinine excretions. We found that mean urinary iodine excretion varied from 30 to 87 mu g/l (31 to 91 mu g/24 h). Sample iodine varied from 10 to 260 mu g/l (20 to 161 mu g/24 h). Crude urinary iodine varied more than estimated 24 h iodine excretion (population standard deviation 32 v. 26; individual standard deviation 29 v. 21; Bartlett's test, P