EFFECTS OF SURGICAL DECENTRALIZATION AND NERVE GROWTH-FACTOR ON MATURATION OF ADRENERGIC NEURONS IN A MOUSE SYMPATHETIC-GANGLION
EFFECTS OF SURGICAL DECENTRALIZATION AND NERVE GROWTH-FACTOR ON MATURATION OF ADRENERGIC NEURONS IN A MOUSE SYMPATHETIC-GANGLION
复制标题
DOI：
10.1111/j.1471-4159.1972.tb01461.x
复制
发表时间：
1972-01-01
影响因子：
4.7
通讯作者：
IVERSEN, LL
中科院分区：
文献类型：
--
作者：
BLACK, IB;HENDRY, IA;IVERSEN, LL
给予蛋白质合成抑制剂放线菌酮可防止出生后发育过程中小鼠颈上神经节酪氨酸羟化酶活性的增加。对 4 日龄小鼠的节前神经进行手术切除，可阻止发育过程中神经节中酪氨酸羟化酶和单胺氧化酶活性的正常增加。手术分散化还阻止了神经节大小和细胞数量的发育增加。因此，节前纤维似乎对交感神经节中节后肾上腺素能神经元的生长和生化成熟发挥一般调节作用。对年轻小鼠施用神经生长因子未能消除正常神经支配神经节和分散神经节之间神经节大小、细胞数量和酪氨酸羟化酶活性的差异。然而，神经生长因子导致控制神经节和分散神经节中所有这些参数的增加——这些增加的幅度在控制神经节中最大。给予新生小鼠卡巴胆碱和毒扁豆碱不影响颈上神经节酪氨酸羟化酶活性的正常发育。
The increase in tyrosine hydroxylase activity in mouse superior cervical ganglion during postnatal development was prevented by administration of the protein synthesis inhibitor cycloheximide. Surgical section of the preganglionic nerves in 4‐day‐old mice prevented the normal increases in tyrosine hydroxylase and monoamine oxidase activity in the ganglion during development. Surgical decentralization also prevented the developmental increases in ganglion size and cell numbers. The preganglionic fibres thus appear to exert a general regulatory effect on the growth and biochemical maturation of postganglionic adrenergic neurons in sympathetic ganglia. Administration of nerve growth factor to young mice failed to eliminate the differences in ganglion size, cell numbers and tyrosine hydroxylase activity between normally innervated and decentralized ganglia. Nerve growth factor, however, caused an increase in all these parameters in both control and decentralized ganglia–the magnitude of these increases being greatest in the control ganglia. Administration of carbachol and physostigmine to neonatal mice did not influence the normal development of tyrosine hydroxylase activity in the superior cervical ganglion.