Hypercoagulability in Dogs with Protein-Losing Nephropathy as Assessed by Thromboelastography
Hypercoagulability in Dogs with Protein-Losing Nephropathy as Assessed by Thromboelastography
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DOI：
10.1111/jvim.12067
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发表时间：
2013-05-01
影响因子：
2.6
通讯作者：
Vaden, S. L.
中科院分区：
文献类型：
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作者：
Lennon, E. M.;Hanel, R. M.;Vaden, S. L.
背景蛋白缺失性肾病(PLN)犬存在血栓栓塞性疾病的危险，但导致高凝状态的机制和处于危险状态的犬的数量尚不清楚。目的探讨血栓弹力成像(TEG)与PLN犬血清白蛋白(SALB)、UPC和抗凝血酶活性的关系。动物28只患有PLN(尿蛋白/肌酐比值为2.0)的客户犬和8只对照犬被纳入这项观察性研究。方法测定TEG参数、抗凝血酶活性、血清生化指标及UPC。分析反应时间(R)、凝块形成时间(K)、-角度(-A)、最大波幅(MA)和整体凝块强度(G)。结果PLN犬K值较低(P=.004)，MA值较高(P=.001)。
Background Dogs with protein-losing nephropathy (PLN) are at risk of thromboembolic disease, but the mechanism leading to hypercoagulability and the population of dogs at risk are unknown. Objectives To characterize thromboelastography (TEG) and its association with serum albumin (SALB), UPC, and antithrombin activity in dogs with PLN. Animals Twenty-eight client-owned dogs with PLN (urine protein:creatinine ratio [UPC] >2.0) and 8 control dogs were prospectively enrolled in this observational study. Methods TEG parameters, antithrombin activity, serum biochemical profiles, and UPC were measured. TEG analyses were run in duplicate with kaolin activation; reaction time (R), clot formation time (K), -angle (), maximal amplitude (MA), and global clot strength (G) were analyzed. Results Dogs with PLN had lower K (P=.004), and higher (P=.001), MA (P