Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers
Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers
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DOI：
10.1007/s10238-011-0155-4
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发表时间：
2012-09-01
影响因子：
4.6
通讯作者：
Xing, Xiaojing
中科院分区：
文献类型：
--
作者：
Gu, Xiaohu;Ma, Yegang;Xing, Xiaojing
双糖链蛋白聚糖是一种细胞外基质蛋白，与多种人类癌症的肿瘤发生和发展有关。然而，双糖链蛋白聚糖在结直肠癌中的临床意义仍不清楚。在本研究中，使用定量实时 RT-PCR 分析了来自 55 名结直肠癌患者的 110 个样本（原发性结直肠肿瘤和匹配的邻近正常组织）中的双糖链蛋白聚糖 mRNA 表达。还评估了双糖链蛋白聚糖上调与临床病理数据之间的相关性。我们发现，61.8%（34/55）的结直肠癌组织中双糖链蛋白聚糖表达上调，且结直肠癌组织中双糖链蛋白聚糖的表达显着高于相应的正常组织（P = 0.0264）。此外，统计分析显示双糖链蛋白聚糖上调与肿瘤分化不良（P = 0.009）、淋巴结转移（P = 0.041）和远处转移（P = 0.036）显着相关。然而，双糖链蛋白聚糖上调与其他临床病理因素之间无显着相关性（均P > 0.05）。总之，双糖链蛋白聚糖可能是结直肠癌恶性程度的潜在标志物。
Biglycan, an extracellular matrix protein, has been implicated in the oncogenesis and cancer development in various types of human cancer. The clinical significance of biglycan in colorectal cancer, however, remains unclear. In the present study, biglycan mRNA expression was analyzed in 110 samples (primary colorectal tumor and matched adjacent normal tissue) derived from 55 patients with colorectal cancer using quantitative real-time RT-PCR. The correlations between biglycan up-regulation and the clinicopathological data were also evaluated. We found that the up-regulation of biglycan occurred in 61.8% (34/55) of colorectal cancer tissues, and biglycan expression in colorectal cancer tissues was markedly higher than that in corresponding normal tissues (P = 0.0264). Moreover, statistical analysis displayed a significant correlation in biglycan up-regulation with poor tumor differentiation (P = 0.009), lymph node metastasis (P = 0.041), and distant metastasis (P = 0.036). However, there was no significant correlation between biglycan up-regulation and other clinicopathological factors (all P > 0.05). In conclusion, biglycan may be a potential marker for the malignancy of colorectal cancer.