Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product
Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product
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对彭亨布鲁虫的研究。
DOI：
10.1017/s0022149x00026663
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发表时间：
1976
影响因子：
1.6
通讯作者：
B. Andrews
中科院分区：
文献类型：
--
作者：
D. Denham;R. Suswillo;R. Rogers;P. McGreevy;B. Andrews
摘要F151是一种有效的杀丝虫剂，对猫和沙鼠体内的伯氏丝虫成虫有较强的杀灭作用。HOE 33258不能杀死猫体内蠕虫，但对沙鼠腹腔内的蠕虫有轻微影响。它不能立即杀死猫的微丝蚴，但给药猫的微丝蚴计数在给药后几周内下降。这两种化合物（V5851 = E）的反应产物或混合物在猫和沙鼠中具有强烈的杀大型丝虫作用。
ABSTRACT F151 was a potent filaricide against adult Brugia pahangi in cats and jirds. HOE 33258 did not kill adult worms in cats but had a marginal effect on adult worms in the peritoneal cavity of jirds. It was not immediately microfilaricidal in cats but the microfilarial counts of treated cats fell within a few weeks of treatment. The reaction product, or mixture, of these two compounds (V5851 = E) was strongly macrofilaricidal m cats and jirds.