Effect of Chlamydiaphage phiCPG1 on the course of conjunctival infection with "Chlamydia caviae" in guinea pigs.
Effect of Chlamydiaphage phiCPG1 on the course of conjunctival infection with "Chlamydia caviae" in guinea pigs.
复制标题
衣原体 phiCPG1 对豚鼠“豚鼠衣原体”结膜感染过程的影响。
DOI：
10.1128/iai.01109-08
复制
发表时间：
2009
影响因子：
3.1
通讯作者：
Bavoil,PatrikM
中科院分区：
文献类型：
--
作者：
Rank,RogerG;Bowlin,AnneK;Cane,Stefania;Shou,Huizhong;Liu,Zhi;Nagarajan,UmaM;Bavoil,PatrikM
Over the last several years, four different phages of chlamydiae, in addition to a phage associated withChlamydia psittaciisolated from an ornithosis infection in ducks over 25 years ago, have been described and characterized. While these phages and their chlamydial host specificities have been characterized in vitro, there is virtually nothing known about the interaction of the phage with chlamydiae in their natural animal host. φCPG1 is a lytic phage specific for “Chlamydia caviae,” which is a natural parasite of the guinea pig. In this study, guinea pigs were inoculated in the conjunctiva with suspensions of φCPG1 andC. caviaeand the effect on the development of pathology and on the course of chlamydial infection in the conjunctiva was determined. The presence of phage delayed the appearance of the peak level of chlamydiae in the animal and decreased the pathological response. Evidence for replication of the phage inC. caviaein the conjunctival tissue was observed. Modifying the ratio of phage to chlamydiae altered the course of infection and affected phage replication. There was no evidence for the phage increasing the virulence ofC. caviaeinfection.
