Inter-Vendor Reproducibility of Pseudo-Continuous Arterial Spin Labeling at 3 Tesla
Inter-Vendor Reproducibility of Pseudo-Continuous Arterial Spin Labeling at 3 Tesla
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DOI：
10.1371/journal.pone.0104108
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发表时间：
2014-08-04
期刊：
影响因子：
3.7
通讯作者：
Nederveen, Aart J.
中科院分区：
文献类型：
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作者：
Mutsaerts, Henri J. M. M.;Steketee, Rebecca M. E.;Nederveen, Aart J.
目的：在临床多中心研究中实施动脉自旋标记（ASL）之前，确定其供应商间的现状重现性非常重要。本研究评价和比较了GE和Philips.Material和Methods临床实施的伪连续ASL（pCASL）的供应商内和供应商间的可重复性：22名健康志愿者在3T GE和3T Philips扫描仪上扫描两次。供应商之间实现的主要差异在于读出模块：螺旋3D快速自旋回波与2D梯度回波回波平面成像。结果：两个供应商的总灰质（GM）和白色物质（WM）的平均脑血流量几乎相等（p = 1.0），而WM的平均脑血流量有显著差异（p <0.01）。
Purpose: Prior to the implementation of arterial spin labeling (ASL) in clinical multi-center studies, it is important to establish its status quo inter-vendor reproducibility. This study evaluates and compares the intra-and inter-vendor reproducibility of pseudo-continuous ASL (pCASL) as clinically implemented by GE and Philips.Material and Methods: 22 healthy volunteers were scanned twice on both a 3T GE and a 3T Philips scanner. The main difference in implementation between the vendors was the readout module: spiral 3D fast spin echo vs. 2D gradient-echo echo-planar imaging respectively. Mean and variation of cerebral blood flow (CBF) were compared for the total gray matter (GM) and white matter (WM), and on a voxel-level.Results: Whereas the mean GM CBF of both vendors was almost equal (p = 1.0), the mean WM CBF was significantly different (p