Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults
Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged Adults
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DOI：
10.3390/nu12020281
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发表时间：
2020-02-01
期刊：
影响因子：
5.9
通讯作者：
Amaro-Gahete, Francisco J.
中科院分区：
文献类型：
--
作者：
Jurado-Fasoli, Lucas;Castillo, Manuel J.;Amaro-Gahete, Francisco J.
背景：可溶性Klotho （S-Klotho）是一种与炎症密切相关的衰老抑制因子。然而，饮食炎症潜能是否与S-Klotho血浆水平相关尚不清楚。我们旨在研究久坐不动的中年成年人饮食炎症指数（DII）与S-Klotho血浆水平的关系。方法：73名久坐不动的中年成年人（40-65岁）参与了本研究。DII是通过24小时召回和食物频率问卷调查获得的28种膳食项目来确定的。采用固相夹心酶联免疫吸附法测定S-Klotho血浆水平。结果：DII与S-Klotho血浆水平呈弱正相关（β = 52.223, R-2 = 0.057, p = 0.043），控制体重指数后消失（p = 0.057）。结论：在久坐不动的中年成年人中，用DII测量的促炎饮食模式与S-Klotho血浆水平有轻微的正相关。
Background: Soluble Klotho (S-Klotho) is an aging suppressor with a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with S-Klotho plasma level. We aimed to investigate the association of the Dietary Inflammatory Index (DII) with S-Klotho plasma levels in middle-aged sedentary adults. Methods: 73 middle-aged sedentary adults (40-65 years old) participated in the present study. DII was determined from 28 dietary items obtained by 24 h recalls and food frequency questionnaires. The S-Klotho plasma levels were measured using a solid-phase sandwich enzyme-linked immunosorbent assay. Results: a weak positive association was observed between DII and S-Klotho plasma levels (beta = 52.223, R-2 = 0.057, p = 0.043), which disappeared after controlling for body mass index (p = 0.057). Conclusions: A pro-inflammatory dietary pattern measured with the DII was slightly and positively associated with S-Klotho plasma levels in middle-aged sedentary adults.