Aberrant angiogenesis: The gateway to diabetic complications.
Aberrant angiogenesis: The gateway to diabetic complications.
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DOI：
10.4103/2230-8210.102992
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发表时间：
2012-11
影响因子：
--
通讯作者：
Modi KD
中科院分区：
文献类型：
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作者：
Kota SK;Meher LK;Jammula S;Kota SK;Krishna SV;Modi KD
糖尿病是一种代谢和血管综合征，导致微血管和大血管系统的异常。糖尿病的不良长期影响已被描述为涉及许多器官系统。除高血糖外，血管生成异常也可能导致或促成糖尿病的许多临床表现。这些与视网膜、肾脏和胎儿血管异常、伤口愈合受损、移植器官排斥反应风险增加和冠状侧支形成障碍的发病机制有关。血管生成异常的一个令人困惑的特征是，在同一个体的不同器官中，血管生成可能过度和不足。本文综述了糖尿病血管生成异常的分子机制，包括生长因子、细胞因子和代谢紊乱的异常、临床意义和治疗选择。
Diabetes Mellitus is a metabolic cum vascular syndrome with resultant abnormalities in both micro- and macrovasculature. The adverse long-term effects of diabetes mellitus have been described to involve many organ systems. Apart from hyperglycemia, abnormalities of angiogenesis may cause or contribute toward many of the clinical manifestations of diabetes. These are implicated in the pathogenesis of vascular abnormalities of the retina, kidneys, and fetus, impaired wound healing, increased risk of rejection of transplanted organs, and impaired formation of coronary collaterals. A perplexing feature of the aberrant angiogenesis is that excessive and insufficient angiogenesis can occur in different organs in the same individual. The current article hereby reviews the molecular mechanisms including abnormalities in growth factors, cytokines, and metabolic derangements, clinical implications, and therapeutic options of dealing with abnormal angiogenesis in diabetes.