Plasma lipids and lipoproteins in young insulin-dependent diabetic patients: relationship with control.
Plasma lipids and lipoproteins in young insulin-dependent diabetic patients: relationship with control.
复制标题
年轻胰岛素依赖型糖尿病患者的血浆脂质和脂蛋白：与对照的关系。
作者：
Lopes-Virella,MF;Wohltmann,HJ;Loadholt,CB;Buse,MG
本文测定了106例（男性56例，年龄2-22岁）胰岛素依赖型糖尿病患者和36例（男性19例）年龄、性别分布相似的正常人的血浆胆固醇、甘油三酯、血糖和血红蛋白A1 c浓度。根据24小时糖尿和血红蛋白A1 c浓度，将糖尿病患者进一步分为三个亚组：“良好”、一般和差控制。总的，低密度脂蛋白和极低密度脂蛋白胆固醇水平显着增加男性患者在控制不良时，与“良好”控制组和正常人相比。甘油三酯和极低密度脂蛋白甘油三酯水平在控制不良的雄性动物中也显著升高。然而，最显着的差异是控制不良的男性患者的高密度脂蛋白胆固醇降低。男性糖尿病患者血红蛋白A1 c与高密度脂蛋白胆固醇呈负相关（r = -0.63），与低密度脂蛋白胆固醇（r = 0.35）和甘油三酯（r = 0.62）呈正相关。女性中的结果相似。观察到最显著的变化是低密度脂蛋白胆固醇水平，控制不良的雌性比控制不良的雄性更明显升高。对于所研究的任何血浆和脂蛋白脂质，在良好和一般控制的组之间没有发现统计学显著差异。然而，在控制不良和控制良好方面，两组之间存在显着差异。在女性中，血红蛋白A1 c与低密度脂蛋白胆固醇水平（r = 0.43）、血红蛋白A1 c与甘油三酯水平（r = 0.54）显著相关，血红蛋白A1 c与高密度脂蛋白胆固醇水平（r = -0.59）呈负相关。
Plasma and lipoprotein cholesterol and triglycerides, glucose and haemoglobin A1cconcentrations were measured in 106 patients (56 males) with insulin-dependent diabetes mellitus (age range 2–22 years) and 36 normal volunteers (19 males) with similar age and sex distribution. The diabetic patients were further divided into three subgroups: “good”, fair and poor control, based on 24 h glycosuria and haemoglobin A1cconcentrations. Total, low density lipoprotein and very low density lipoprotein cholesterol levels were significantly increased in male patients in poor control when compared with the group in “good” control and with normal subjects. Triglyceride and very low density lipoprotein triglyceride levels were also significantly increased in poorly controlled males. The most significant difference however was a decrease of high density lipoprotein cholesterol in male patients in poor control. There was a significant inverse correlation between haemoglobin A1cand high density lipoprotein cholesterol (r = -0.63) and a direct correlation between haemoglobin A1cand low density lipoprotein cholesterol (r = 0.35) and triglycerides (r = 0.62) in the male diabetics. The findings were similar in females. The most striking change was observed in low density lipoprotein cholesterol levels, which were more markedly increased in poorly controlled females than in poorly controlled males. No statistical singificant differences were found between the groups in good and fair control for any of the plasma and lipoprotein lipids studied. A significant difference however was found between the groups in poor and fair control. There was a significant correlation in females between haemoglobin A1cand low density lipoprotein cholesterol levels (r = 0.43), haemoglobin A1cand triglycerides levels (r = 0.54) and an inverse correlation between haemoglobin A1cand high density lipoprotein cholesterol (r = -0.59).