A follow-up study of synthetic rubber workers
A follow-up study of synthetic rubber workers
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DOI：
10.1016/0300-483x(96)03443-9
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发表时间：
1996-10-28
期刊：
影响因子：
4.5
通讯作者：
Muir, DCF
中科院分区：
文献类型：
--
作者：
Delzell, E;Sathiakumar, N;Muir, DCF
虽然1,3-丁二烯（ED）已被列为动物致癌物，但流行病学研究报告的ED与人类淋巴系统和其他癌症之间的关系结果不一致。本研究评估了在北美八家丁苯橡胶（SBR）工厂工作至少一年的15649名男性的死亡率经验。大约75%的受试者暴露于ED；83%暴露于苯乙烯（STY）。在1943-1991年期间，该队列共有386 172人，平均随访25人年，观察到3976人死亡，而根据一般人群死亡率(标准化死亡率（SMR) = 87, 95%置信区间(CI)= 85-90）预计死亡人数为4553人。在整个队列中（48例观察/37例预期，SMR = 131, CI = 97-174）和每小时一次的受试者中（45/32,SMR = 143, CI = 104-191）出现了高于预期的白血病死亡。过量集中在每小时工作10年以上和雇佣20年以上的受试者中（28/13,SMR = 224, CI = 149-323），以及聚合（15/6.0,SMR = 251, CI = 140-414）、维护劳动力（13/4.9,SMR = 265, CI = 141-453）和实验室（10/2.3,SMR = 431, CI = 207-793），这三个领域对ED或STY单体的暴露可能相对较高。除白血病外，一些队列亚组的淋巴系统癌症死亡率略有增加，但SBR行业内按种族、工作年限和工艺组划分的死亡率模式并未表明与职业暴露有因果关系。这些结果表明，SBR工业中的暴露会导致白血病。
Although 1,3-butadiene (ED) has been classified as an animal carcinogen, epidemiologic research has reported inconsistent results on the relationship between ED and lymphopoietic and other cancers in humans. This study evaluated the mortality experience of 15 649 men employed for at least 1 year at any of eight North American styrene-butadiene rubber (SBR) plants. About 75% of the subjects were exposed to ED; 83% were exposed to styrene (STY). During 1943-1991, the cohort had a total of 386 172 and an average of 25 person-years of follow-up, with 3976 deaths observed compared to 4553 deaths expected based on general population mortality rates (standardized mortality ratio (SMR) = 87, 95% confidence interval (CI)= 85-90). More than expected leukemia deaths occurred in the overall cohort (48 observed/37 expected, SMR = 131, CI = 97-174) and among ever hourly subjects (45/32, SMR = 143, CI = 104-191). The excess was concentrated among ever hourly subjects with 10+ years worked and 20+ years since hire (28/13, SMR = 224, CI = 149-323) and among subjects in polymerization (15/6.0, SMR = 251, CI = 140-414), maintenance labor (13/4.9, SMR = 265, CI = 141-453) and laboratories (10/2.3, SMR = 431, CI = 207-793), three areas with potential for relatively high exposure to ED or STY monomers. Some cohort sub-groups had slight increases in deaths from lymphopoietic cancers other than leukemia, but mortality patterns by race, years worked and process group within the SBR industry did not indicate a causal association with occupational exposures. These results indicate that exposures in the SBR industry cause leukemia.